CAS: 3172-52-9; 2,5-Dichlorothiophene

上下游产品

CAS号188290-36-0 Thiophene(SIV) | CAS号96-43-5 2-氯噻吩 | CAS号36157-41-2 2,5-二氯-3-噻吩甲酸 | CAS号527-72-0 2-噻吩甲酸 | CAS号598-49-2 乙醯氯胺 | CAS号64048-11-9 2,3,4,5-tetrach... | CAS号7732-18-5 水 | CAS号64-17-5 乙醇 | CAS号36157-40-1 2,5-二氯-3-乙酰基噻吩 | CAS号36157-41-2 2,5-二氯-3-噻吩甲酸 | CAS号6012-97-1 四氯噻吩 | CAS号40477-45-0 3,4-二溴-2,5-二氯噻吩 | CAS号50478-16-5 5-氯-2-噻吩甲腈 | CAS号18853-40-2 2,5-二氰基噻吩 | CAS号51584-21-5 2,5-二氯-3,4-二硝基噻吩 | CAS号37105-12-7 2,5-dichloro-3-... | CAS号2404-97-9 5-chlorothiophe... | CAS号53381-41-2 2-chloro-5-(5-c...

噻吩置于n-氯代丁二酰亚胺,高氯酸体系中,用 氯仿 用作溶剂,化学反应 0.5H,以67%的收率获得2,5-二氯噻吩
参考文献:Synthesis And Structural Characterization Of 2,5-Dihalo-3,4-Dinitrothiophenes
标题:Synthesis And Structural Characterization Of 2,5-Dihalo-3,4-Dinitrothiophenes
摘要:通过使用新的硝化方案,我们能够高效地对 2,5-二卤噻吩进行二硝化反应,产率可达 ∼ 80-95%.所得产物 2,5-二溴-3,4-二硝基噻吩 (1),2,5-二氯-3,4-二硝基噻吩 (2),2-溴-5-氯-3,4-二硝基噻吩 (3) 以及类似的 2-溴-3,4-二硝基噻吩 (4),都很容易结晶,可以通过 X 射线晶体学进行表征.1 结晶于单斜空间群 C2/c,A = 14.547(3) 埃,B = 7.3534(15) 埃,C = 10.775(2) 埃,β = 128.89(3)°,Z = 4.2置于i-42D 四方空间群中结晶,A = 9.9398(14) 埃,B = 9.9398(14) 埃,C = 16.866(3) 埃,Z = 8.3 在三菱空间群 P-1 中结晶为假正四面体孪晶,A = 7.340(5) 埃,B = 8.094(5) 埃,C = 9.4 在三菱空间群 P-1 中结晶,A = 7.1787(14) 埃,B = 7.4092(15) 埃,C = 8.3151(17) 埃,α = 101.67(3)°,β = 96.00(3)°,γ = 116.13(3)°,Z = 2.由于卤素和硝基之间的卤键相互作用,所有化合物的结构都显示出形成了有趣的固态组合体.
Doi:10.1007/s10870-006-9160-Y

专利信息

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:WO-2007141253-A1
优先权日:2006-06-07
标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-5211889-A
优先权日:1991-08-01
标 题:Soluble highly reactive form of calcium and reagents thereof
发明人：RIEKE REUBEN D
权利人:UNIV NEBRASKA
摘要:A soluble highly reactive form of calcium, prepared from Ca(II) salts and a reducing agent in ethereal, polyethereal, or hydrocarbon solvents, is presented. This form of calcium can be used in the preparation of organocalcium reagents. The organocalcium reagents resulting from the reaction of the soluble highly reactive calcium with organic compounds containing either halide, cyanide, a 1,3-diene, or a polyunsaturated functionality, are stable, useful reagents for organic synthesis. The organocalcium halide reagents undergo Grignard-type reactions. They also undergo reactions with Cu(I) salts to form organocalcium cuprate reagents. The organocalcium cuprate reagents undergo a variety of cross-coupling reactions. The soluble highly reactive calcium reacts with 1,3-dienes to yield the corresponding 2-butene-1,4-diylcalcium complexes. These bis-organocalcium reagents can undergo dialkylation reactions with α,ω-alkylene dihalides and dichlorosilanes to form the corresponding 3-, 5-, and 6-membered ring derivatives. The soluble highly reactive calcium also reacts with organic dihalides to form mono- or diorganocalcium compounds which can be converted into a wide variety of polymers.

专利号:US-5384078-A
优先权日:1991-08-01
标 题:Soluble highly reactive form of calcium and reagents thereof
发明人：RIEKE REUBEN D
权利人:UNIV NEBRASKA
摘要:A soluble highly reactive form of calcium, prepared from Ca(II) salts and a reducing agent in ethereal, polyethereal, or hydrocarbon solvents, is presented. This form of calcium can be used in the preparation of organocalcium reagents. The organocalcium reagents resulting from the reaction of the soluble highly reactive calcium with organic compounds containing either halide, cyanide, a 1,3-diene, or a polyunsaturated functionality, are stable, useful reagents for organic synthesis. The organocalcium halide reagents undergo Grignard-type reactions. They also undergo reactions with Cu(I) salts to form organocalcium cuprate reagents. The organocalcium cuprate reagents undergo a variety of cross-coupling reactions. The soluble highly reactive calcium reacts with 1,3-dienes to yield the corresponding 2-butene-1,4-diylcalcium complexes. These bis-organocalcium reagents can undergo dialkylation reactions with α,ω-alkylene dihalides and dichlorosilanes to form the corresponding 3-, 5-, and 6-membered ring derivatives. The soluble highly reactive calcium also reacts with organic dihalides to form mono- or diorganocalcium compounds which can be converted into a wide variety of polymers.

专利号:EP-2826772-A1
优先权日:2010-01-26
标题 :Intermediates for the synthesis of oxygen-substituted 3-heteroaroylamino-propionic acid derivatives