CAS: 34784-04-8; 5-Bromoisoquinoline

相似化合物

58794-09-5 223671-10-1 1532-97-4

上下游产品

CAS号119-65-3 异喹啉 | CAS号1125-60-6 5-氨基异喹啉 | CAS号497863-61-3 N-[(3-溴苯基)亚甲基]-... | CAS号1336-21-6 氨水 | CAS号3132-99-8 间溴苯甲醛 | CAS号645-36-3 氨基乙醛缩二乙醇 | CAS号7664-93-9 硫酸 | CAS号63927-20-8 (3-bromo-benzyl... | CAS号105685-17-4 5-哌嗪-1-基-异喹啉 | CAS号104737-00-0 5-溴-2-甲基-8-硝基-1... | CAS号34784-07-1 8-氯异喹啉 | CAS号371766-08-4 异喹啉-5-硼酸 | CAS号90721-35-0 5-溴-8-氨基异喹啉 | CAS号34551-41-2 5-溴-1-氯异喹啉 | CAS号23687-27-6 8-氨基异喹啉 | CAS号80278-67-7 异喹啉-5-甲醛 | CAS号119-65-3 异喹啉 | CAS号1210329-82-0 5-(2,5-dimethyl...

异喹啉置于n-溴代丁二酰亚胺(Nbs),硫酸体系中,化学反应 4.0H,以79%的收率获得产物5-溴异喹啉
参考文献:异喹啉碳环核的区域穷竭功能化:氧杂卟啉核和玫瑰树碱的合成
标题:异喹啉碳环核的区域穷竭功能化:氧杂卟啉核和玫瑰树碱的合成
摘要:摘要 已经开发了用于异喹啉碳环核心功能化的通用且通用的策略.这种区域穷举性方法采用亲电子卤化作为工具箱方法,并提供了装饰精美的中间体,可以将其进一步加工成与医学相关的构件或天然产物. 已经开发了用于异喹啉碳环核心功能化的通用且通用的策略.这种区域穷举性方法采用亲电子卤化作为工具箱方法,并提供了装饰精美的中间体,可以将其进一步加工成与医学相关的构件或天然产物.
DOI:10.1055/s-0037-1609153

专利信息

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-8058477-B2
优先权日:2006-03-21
标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
发明人：HARTWIG JOHN F; SHEN QILONG
权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

专利号:US-6500954-B1
优先权日:1998-06-22
标 题:Synthesis of 5- or 8-bromoisoquinoline derivatives
发明人：GOULIAEV ALEX HAAHR; HANSEN WILLIAM
权利人:NEUROSEARCH AS
摘要:The present invention is directed to a method of preparing bromoisoquinoline derivatives, in particular 5- or 8-bromoisoquinoline derivatives. Bromoisoquinoline derivatives, and in particular 5-bromoisoquinoline and 5-bromo-8-nitroisoquinoline derivatives, are key intermediates in the synthesis of pharmaceutical compounds.

专利号:US-2023183246-A1
优先权日:2020-05-19
标题 :Continuous flow sonogashira coupling synthesis method
发明人：THOMPSON DAVID HARLEY; SINTIM HERMAN O; QI QINGQING; BIYANI SHRUTI
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation.

专利号:US-10125226-B2
优先权日:2013-06-05
标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils
发明人：FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR
权利人:MEXICANO INST PETROL
摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.

专利号:US-2009234126-A1
优先权日:2006-03-21
标 题:Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide