CAS: 42971-09-5; (41S,13As)-Ethyl 13A-Ethyl-2,3,41,5,6,13A-Hexahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5]Naphthyridine-12-Carboxylate

上下游产品

CAS号64-17-5 乙醇 | CAS号4880-92-6 长春西汀杂质B | CAS号40163-56-2 长春胺乙酯 | CAS号141-52-6 乙醇钠 | CAS号23944-42-5 (-)-1β-methoxyc... | CAS号82398-60-5 dl,cis-14-Oxo-1... | CAS号1617-90-9 长春胺 | CAS号77793-33-0 (+/-)-1α-ethyl-... | CAS号85647-38-7 (+/-)-ethyl-(1,...

长春胺乙酯置于甲烷磺酸体系中,化学反应 8.0H,以79%的收率获得产物长春西汀
参考文献:长春西汀的简便一锅法合成
标题:长春西汀的简便一锅法合成
摘要:摘要 建立了以长春胺为原料一锅法合成长春西汀的方法.路易斯酸导致长春胺在乙醇中发生酯交换和/或脱水.fecl3 催化酯交换和脱水,而 Ti(Oet)4 选择性催化酯交换.
DOI:10.1080/00397919408011297

专利信息

专利号:US-2007197797-A1
优先权日:2005-12-30
标 题 :Compounds and methods for carbazole synthesis
发明人：HARRINGTON PETER J
权利人:HARRINGTON PETER J
摘要:Compounds having bi-cyclic structure comprising a partially unsaturated 6-carbon first cyclic moiety interconnected to a 6-carbon second cyclic moiety second via a divalent linking moiety are provided. The compounds can be used as intermediates compounds in methods for the synthesis of carbazoles and derviatives thereof, including carvedilol, and tricyclic alkylhydroxamates, which do not require Fischer indole synthetic steps. Methods of preparing the compounds having bi-cyclic structures are also provided.

专利号:WO-9964032-A1
优先权日:1998-06-08
标题 :Combinatorial synthesis of multibinding libraries
发明人：CHRISTENSEN BURTON G; GRIFFIN JOHN H; JENKINS THOMAS E; JUDICE J KEVIN
权利人:ADVANCED MEDICINE INC; CHRISTENSEN BURTON G; GRIFFIN JOHN H; JENKINS THOMAS E; JUDICE J KEVIN
摘要:Disclosed are methods for synthesizing large collections of diverse multimeric compounds as well as iterative processes for evaluating key molecular constraints imparting multibinding properties to multimeric compounds. Also disclosed are libraries of multimeric compounds which can be evaluated for imparting multibinding properties.

专利号:US-2006014773-A1
优先权日:2001-04-19
标题:Mental agility lozenge, edible strip, food or drink
发明人：MCCLEARY EDWARD L
权利人:MCCLEARY EDWARD L
摘要:A mental agility composition is composed of at least one agent which promotes synthesis of ATP and/or creatine phosphate in the body; at least one antioxidant for scavenging free radicals in at least one pathway in the body; at least one agent for normalizing or maintaining membrane function and structure in the body; at least one agent for normalizing or maintaining normal neurotransmitter function in the body; at least one agent for down-regulating cortisol action; and at least one agent for suppressing activation of apoptotic pathways in the body. The composition may further contain one or more of at least one agent for suppressing inflammation in the body; at least one agent for normalizing or maintaining vascular wall function and structure in the body; at least one agent for normalizing or maintaining function of nerve growth factors and/or neurotropic factors in the body; at least one agent for suppressing toxic metal ionic effects; at least one agent for normalizing or maintaining methyl metabolism in the body; at least one agent for normalizing or maintaining metabolism of insulin and glucose in the body; and at least one agent for up-regulating activity of heat shock proteins in the body. The composition is administered in the form of a breath-care strip, mint or lozenge, or a food or beverage product.

专利号:US-7420070-B2
优先权日:2000-12-28
标 题:Process for preparing optically active 2,3-dihydrobenzofuran compounds
发明人：AOKI ISAO; ADACHI MARI; TAWADA HIROYUKI; YAMASHITA MAKOTO; SERA MISAYO
权利人:TAKODA PHARMACEUTICAL COMPANY
摘要:A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: n n[wherein R 1 and R 2 are each hydrogen or an optionally substituted hydrocarbon group; R 3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2022125711-A1
优先权日:2020-10-23
标题 :Cannabinoid-containing oral thin film formulations
发明人：BAJAJ AKHIL; WEBB SKYLER; HOOSEIN SHEHZAD; RASHKOW ANDREW
权利人:JDEM PROPERTIES LLC
摘要:The methods disclosed herein permit the synthesis of cannabinoid-containing oral thin film (OTF) strips that also contain caffeine or multiple additional active ingredients. Selection of film forming agents based on water usage coupled with low temperature mixing and low temperature drying may in various embodiments permit the incorporation of up to five additional ingredients into a cannabinoid containing OTF product.