CAS: 431-05-0; 1,1-Difluoroacetone

相似化合物

431-04-9 381-88-4 142492-01-1

上下游产品

CAS号126266-75-9 3,3-二氯-1,1,1-三氟... | CAS号454-31-9 二氟乙酸乙酯 | CAS号75-16-1 甲基溴化镁 | CAS号513-88-2 1,1-二氯丙酮 | CAS号431-37-8 1-氯-3,3,3-三氟丙酮 | CAS号758-42-9 1,1,3-三氯-1,3,3-三氟丙酮 | CAS号352-24-9 二氟乙酰乙酸乙酯 | CAS号431-04-9 1,1-二氟丙烷-2-醇

1,1-二氯丙酮置于potassium Hydrogen Bifluoride体系中,用 二乙二醇 作为反应溶剂,化学反应生成 1,1-二氟丙酮
参考文献:包括1-溴-1-氯-1-氟丙酮在内的一些卤代丙酮的制备
标题:包括1-溴-1-氯-1-氟丙酮在内的一些卤代丙酮的制备
摘要:通过一氯丙酮的二溴化反应,然后在严格控制的条件下,与氟化汞进行交换反应,用氟代替一个溴原子,从而制得1-溴-1-氯-1-氟丙酮.
DOI:10.1039/j39710000279

专利信息

专利号:US-2022372000-A1
优先权日:2021-05-05
标 题:New Process for the Synthesis of 5-Fluoro-3-(Difuoromethyl)-5-Fluoro-1-Methyl-1H-Pyrazole-4-Carboxylic Acid Derivatives and the Free Acid Thereof
发明人：LUO WEIFEN; WU WENTING
权利人:FUJIAN YONGJING TECH CO LTD
摘要:The invention provides a new process for the synthesis of 5-fluoro-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid derivatives and the free acid thereof, involving a direct fluorination reaction with a fluorination gas comprising or consisting of elemental fluorine (F2), in a reactor which is resistant to elemental fluorine (F2) and hydrogen fluoride (HF), and wherein in the process as a starting material a difluoromethyl-pyrazole compound dissolved in an inert solvent is subjected to the direct fluorination reaction. Some particular examples of 5-fluoro-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid derivatives which can be prepared according to the process of the invention are 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid fluoride (5F-DFMPAF), also known under the alternative name 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl fluoride; 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid ethylester (5F-DFMP); and 3-(chlorodifluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid ethylester (5F-CDFMP), or the corresponding methyl esters. The 5-fluoro-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid can be obtained from its carboxylic acid derivatives such as, e.g., mentioned before in that the acid derivative is converted to the corresponding carboxylic acid.

专利号:US-9809534-B1
优先权日:2014-07-21
标 题 :Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof
发明人：LUKIN KIRILL A; MEI JIANZHANG; HILL DAVID R; ABRAHAMSON MICHAEL J
权利人:ABBVIE INC
摘要:The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

专利号:EP-4103553-A1
优先权日:2021-05-05
标 题:New process for the synthesis of 5-fluoro-3- (difuoromethyl) -5-fluoro-1-methyl-1h-pyrazole-4-carboxylic acid derivatives and the free acid thereof

专利号:CN-114450269-A
优先权日:2021-05-05
标题:A new method for the synthesis of 5-fluoro-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid derivatives and their free acids

专利号:CN-118852012-A
优先权日:2024-09-26
标 题:Synthesis method of high-yield difluoro pyrazole acid

专利号:CN-118515614-A
优先权日:2024-05-21
标 题:Synthesis method of difluoro pyrazole acid