CAS: 577-19-5; 1-Bromo-2-Nitrobenzene

上下游产品

CAS号88-74-4 2-硝基苯胺 | CAS号615-36-1 2-溴苯胺 | CAS号108-86-1 溴苯 | CAS号552-16-9 2-硝基苯甲酸 | CAS号609-73-4 邻硝基碘苯 | CAS号244205-40-1 2-溴苯硼酸 | CAS号101420-81-9 3-溴-4-硝基苯甲酸 | CAS号98-95-3 硝基苯 | CAS号132993-22-7 (2-nitrophenyl)... | CAS号14527-90-3 2-nitroaniline ... | CAS号10565-14-7 二乙基(2-硝基苯基)丙二酸酯 | CAS号574-39-0 9-乙酰基咔唑 | CAS号40787-96-0 3-溴-4-硝基苯胺 | CAS号606-27-9 2-硝基苯甲酸甲酯 | CAS号55578-79-5 2-(2-呋喃基)苯胺 | CAS号38089-03-1 4-甲氧基联苯-2-胺 | CAS号54381-13-4 4-甲氧基-2'-硝基联苯胺 | CAS号13073-25-1 2-溴-6-硝基苯酚 | CAS号5847-59-6 2-溴-4-硝基苯酚 | CAS号5470-65-5 3-溴-4-硝基苯酚

1,2-二硝基苯置于高氯酸,硫酸,Sodium Nitrite,氢溴酸,铜体系中,用 水,乙酸乙酯 作为反应溶剂,以60%的收率获得产物1-溴-2-硝基苯
参考文献:芳基重氮盐的两相电化学反应生成:在电反应生成的铜催化的桑德迈尔反应中的应用.
标题:芳基重氮盐的两相电化学反应生成:在电反应生成的铜催化的桑德迈尔反应中的应用.
摘要:首次报道了在两相系统(乙酸乙酯/水)中由硝基芳烃电化学反应生成芳基重氮盐.以非常好的收率和非常好的纯度制备了包括偶氮,偶氮砜和芳基叠氮化物在内的一些化合物.阴极产生的芳基重氮和阳极产生的铜(i)离子用于进行sandmeyer反应.为了改进该方法,引入了以zn棒为阳极的h型自驱动电池,并将其用于两相芳基重氮的生产.
DOI:10.1021/acs.Orglett.0C02013

专利信息

专利号:WO-03031376-A1
优先权日:2001-10-12
标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
发明人：MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:WO-2004096766-A1
优先权日:2003-04-29
标题 :A method of indole synthesis
发明人：BANWELL MARTIN GERHARDT; LUPTON DAVID WILLIAM
权利人:UNIV AUSTRALIAN; BANWELL MARTIN GERHARDT; LUPTON DAVID WILLIAM
摘要:The present invention relates to methods for the synthesis of indoles. In particular, the invention relates to the coupling of an a-haloenone or a-haloenal with an ortho-halonitroarene to form an ortho-(enone)nitroarene or ortho-(enal)nitroarene. Reductive cyclization of an ortho-(enone)nitroarene or ortho-(enal)nitroarene affords access to indole compounds.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles