CAS: 61849-14-7; Sodium (Z)-5-((3Ar,4R,5R,6As)-5-Hydroxy-4-((S,E)-3-Hydroxyoct-1-En-1-yl)Hexahydro-2H-Cyclopenta[b]Furan-2-Ylidene)Pentanoate

专利信息

专利号:US-4760068-A
优先权日:1982-06-14
标题:Certain pyridyl alkenoic acid derivatives which inhibit the action of thromboxane A2 synthetase
发明人：TERAO SHINJI; NISHIKAWA KOHEI
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:Novel compound of the formula: ##STR1## wherein R 1 is pyridyl group, R 2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R 3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R 4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts having an inhibitory action on bio-synthesis of thromboxane A 2 (TXA 2 ) and an effect of accelerating the productivility of prostaglandin I 2 (PGI 2 ), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

专利号:US-8658837-B2
优先权日:2011-08-24
标 题:Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
发明人：WEI SHIH-YI; HSU MIN-KUAN; HSU MING-KUN
权利人:WEI SHIH-YI; HSU MIN-KUAN; HSU MING-KUN; CHIROGATE INT INC
摘要:Novel processes for preparing optically active cyclopentanones 1 n nwhich are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.

专利号:US-4518602-A
优先权日:1982-10-07
标题 :Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase
发明人：TERAO SHINJI; NISHIKAWA KOHEI
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:Novel compound of the formula: wherein R1 is a pyridyl group; R2 is a phenyl, thienyl, furyl, naphthyl, benzothienyl or pyridyl group which may have as a substituent a lower alkoxy, a lower alkyl, a halogen, trifluoromethyl, a lower alkenyl or methylenedioxy; R3 is hydrogen, benzyl or a lower alkyl; one of R4 and R5 is hydrogen or a lower alkyl, and the other is an aryloxy, or lower aliphatic hydrocarbon, an alicyclic hydrocarbon having not more than 6 carbon atoms or an aromatic group which may have a substituent, or a group represented by the formula, -S(O)m-R6 (in which R6 is phenyl or a lower alkyl group; m is an integer of 0 to 2), or R4 and R5 each combine with the other to represent one alkylene group; n is an integer of 2 to 6, or a pharmaceutically acceptable salt thereof has a selective inhibitory action on bio-synthesis of thromboxane A2(TXA2) and an effect of enhancing the production of prostaglandin I2(PGI2), and can be used in mammals for to prevention and treatment of arterial thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardian infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

专利号:US-8183409-B2
优先权日:2004-05-06
标题:High yield and rapid synthesis methods for producing metallo-organic salts
发明人：CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS
摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.

专利号:US-2013053581-A1
优先权日:2011-08-24
标题 :Intermediates for the synthesis of benzindene prostaglandins and preparations thereof

专利号:JP-6054935-B2
优先权日:2011-08-24
标题:Intermediates for the synthesis of benzoindene prostaglandins and their preparation