专利号:RU-2186055-C2 优先权日:1995-05-24 标 题 :Method of synthesis of derivatives 3-carboxy-4-hydroxybenzaldehyde, method of synthesis of 4-hydroxybenzaldehyde, methods of synthesis of vanillin and ethylvanillin
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-6225341-B1 优先权日:1995-02-27 标 题:Compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A 权利人:GILEAD SCIENCES INC 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-2007161807-A1 优先权日:2004-01-28 标 题:Method for manufacturing optically pure coumaryl amino acids and the novel coumaryl aminoacids thus obtained 发明人:GARBAY CHRISTIANE; BISCHOFF LAURENT; BRUN MARIE-PRISCILLE 权利人:INSERM INST NAT DE LA SANT E E 摘要:The present invention relates to the field of the synthesis of optically pure amino acid derivatives, mainly for the purpose of manufacturing optically active polypeptides that are useful as labelled detection tools.
专利号:EP-0706089-A3 优先权日:1994-10-05 标 题 :Process for the synthesis of a quinonediazide ester and positive working photoresist containing it
专利号:US-7439350-B2 优先权日:1993-09-17 标题 :Nucleotide analogs 发明人:BISCHOFBERGER NORBERT W; JONES ROBERT J; ARIMILLI MURTY N; LIN KUEI-YING; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; LEE WILLIAM A; CUNDY KENNETH C 权利人:GILEAD SCIENCES INC 摘要:Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
参考文献:10.1007/s11095-005-8813-4 摘要:Fedorov SN, Radchenko OS, Shubina LK, Balaneva NN, Bode AM, Stonik VA, Dong Z. Evaluation of Cancer-Preventive Activity and Structure–Activity Relationships of 3-Demethylubiquinone Q2, Isolated from the Ascidian Aplidium glabrum, and its Synthetic Analogs. Pharmaceutical Research. 2006 Jan;23(1):70–81. doi: 10.1007/s11095-005-8813-4.