专利号:US-5827794-A 优先权日:1994-02-22 标 题 :Supported highly-polar liquid phase chiral sulfonated binap catalyst for asymmetric synthesis of optically active compounds 发明人:DAVIS MARK E; WAN KAM TO 权利人:CALIFORNIA INST OF TECHN 摘要:The present invention relates to water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and its use as organometallic catalysts for asymmetric synthesis of optically active compounds. Asymmetric reactions of the present invention include those reactions in which organometallic catalysts are commonly used. Such reactions include, but are not limited to, reduction and isomerization reactions on unsaturated substrates and carbon--carbon bond forming reactions. Examples of such reactions include, but are not limited to, hydrogenation, hydroboration, hydrosilylation, hydride reduction, hydroformylation, alkylation, allylic alkylation, arylation, alkenylation, epoxidation, hydrocyanation, disilylation, cyclization and isomerization reactions. n The catalysts of the present invention provide the advantage of functioning in the presence of water without loss in enantioselectivity relative to the nonsulfonated BINAP catalyst in an organic solvent. As a result, the catalysts of the present invention may be employed in water, water miscible solvents, in aqueous--organic two phase solvent systems and in supported aqueous phase catalysts in organic solvents without loss in enantioselectivity. Further, the catalysts of the present invention may also be effectively employed in highly polar solvents such as primary alcohols and ethylene glycol. n The present invention also relates to a method for conducting asymmetric reactions on prochiral unsaturated bonds contained within a compound using the water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl organometallic catalysts of the present invention.
专利号:WO-2021014395-A1 优先权日:2019-07-24 标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs 发明人:ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT 权利人:DR REDDY’S INST OF LIFE SCIENCES 摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.
专利号:WO-2025030483-A1 优先权日:2023-08-10 标题 :HETEROGENEOUS BIMETALLIC PLATINUM CATALYST AND USE THEREOF IN SYNTHESIS OF γ-CHLOROPROPYLTRICHLOROSILANE 发明人:LIU SHAOFENG; ZHANG HENGCHENG; ZHANG JINBO; ZHAO TIANSHU; WANG CHENGLONG; Liu Bobao; ZHAO JIAWEN; MA MINGDE; LIN XIANGYING 权利人:QINGDAO UNIV OF SCIENCE AND TECHNOLOGY; RIZHAO LANXING CHEMICAL IND CO LTD 摘要:Disclosed in the present invention are a heterogeneous bimetallic platinum catalyst and a use thereof in synthesis of γ-chloropropyltrichlorosilane (γ1). In the present invention, an anthracene skeleton is introduced, a novel bimetallic platinum metal catalyst is synthesized by means of coordination with platinum, and the bimetallic platinum metal catalyst is loaded into high vinyl polybutadiene by means of a Diels-Alder (DA) reaction to prepare the heterogeneous bimetallic platinum catalyst. The novel heterogeneous bimetal platinum catalyst has a synergistic catalytic effect, and high-efficiency and high-selectivity hydrosilylation reaction of non-chloropropene and trichlorosilane is realized. The heterogeneous bimetallic catalyst reported by the present invention has the characteristics of high catalytic efficiency, high selectivity and recyclability, the purity of γ1 reaches 99.5%, and the product yield is as high as 97%.
专利号:US-11873305-B2 优先权日:2020-06-30 标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds 发明人:ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES 权利人:GENENTECH INC; HOFFMANN LA ROCHE 摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.
专利号:US-2022411943-A1 优先权日:2021-06-23 标 题 :Process for the Electrochemical Synthesis of Green Urea, an Electrochemical Cell for the Electrochemical Synthesis of Green Urea and the Green Urea Produced Thereby 发明人:GHORAI UTTAM KUMAR; MUKHERJEE Jit; PAUL SOURAV; ADALDER ASHADUL 权利人:GHORAI UTTAM KUMAR; RAMAKRISHNA MISSION VIDYAMANDIRA 摘要:This invention relates to a process for the electrochemical synthesis of green urea, and the urea produced thereby. The electrochemical synthesis of urea involves the reduction of dual purging gases N 2 and CO 2 via six electron transfer process (N 2 +CO 2 +6H + +6e − →CO (NH 2 ) 2 +H 2 O) & reduction of the NO 3 − ions and CO 2 via sixteen electron transfer process (2NO 3 −+CO 2 +18H + +16e − →CO(NH 2 ) 2 +7H 2 O) under ambient condition using copper phthalocyanine (CuPc) catalyst. The binding of two intermediate products during dual reduction simultaneously, leads to the production of urea in water medium under ambient conditions.
专利号:US-2024075466-A1 优先权日:2021-04-09 标 题:One-Pot Synthesis of Transition Metal-Promoted Chabazites 发明人:VAN TENDELOO LEEN; SCHUETZE FRANK-WALTER; VERHEYEN ELKE JANE JUNE 权利人:UMICORE AG & CO KG 摘要:The invention provides methods for a one-pot synthesis of molecular sieves of the CHA-type. The method uses molecular and non-molecular sieves as sources of silicon and aluminum. A first OSDA is selected from tetraethylenepentamine (TEPA) and triethy-lenepentamine (TETA). The synthesis mixture comprises a first metal selected from copper, iron and zinc. Optionally, the synthesis mixture may furthermore comprise a second OSDA and/or a second metal selected from manganese, cesium, magnesium, calcium, strontium, barium, yttrium, titanium, zirconium, niobium, iron, zinc, silver, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium and mixtures thereof. The molecular sieves of the CHA-type obtainable by the method can be used as SCR-catalytically active substances for the removal of nitrogen oxides from exhaust gases of combustion engines.
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