欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号1007-16-5 3-溴-4-氟苯甲酸 | CAS号77771-02-9 3-溴-4-氟苯甲醛 | CAS号1634-04-4 甲基叔丁基醚 | CAS号206551-41-9 3-溴-2-氟苯甲酸甲酯 | CAS号82702-31-6 3-溴-4-氟苯甲酸甲酯 | CAS号79-22-1 氯甲酸甲酯 | CAS号103-83-3 N,N-二甲基苄胺 | CAS号5197-95-5 苄基三乙基溴化铵 | CAS号541-41-3 氯甲酸乙酯 | CAS号78239-71-1 3-溴-4-氟苄溴 | CAS号77771-02-9 3-溴-4-氟苯甲醛 | CAS号78239-72-2 2-Bromo-4-(chlo... | CAS号887268-22-6 2-溴-1-氟-4-甲氧基甲基苯 | CAS号501420-63-9 3-溴-4-氟苯乙腈3-溴-4-氟苯甲醛 以 四氢呋喃 作为反应溶剂,化学反应生成 3-溴-4-氟苯甲醇
参考文献:Insecticidal Ethers
标题:Insecticidal Ethers
摘要:化学式(I)的杀虫活性化合物:其中r.Sup.4代表从公式中由r.Sup.5代表的那些基团中选择的一个基团.r.Sup.3从氟甲基和二氟甲基中选择,且要么(A) R.Sup.1和r.Sup.2代表碳原子数为一,二,三或四的烷基,要么(B) R.Sup.1和r.Sup.2与相邻的碳原子一起形成四,五或六个碳原子的环烷基环.
专利信息
专利号:US-8273793-B2
优先权日:2007-12-07
标题:Method for producing precursors for L-2- [18F] fluorophenylalanine and 6- [18F] fluoro-L—meta-tyrosine and the α-methylated derivatives thereof, precursor, and method for producing L-2- [18F] fluorophenylalanine and 6- [18F] fluoro-L-meta-tyrosine and the α-methylated derivatives from the precursor
发明人:WAGNER FRANZISKA; ERMERT JOHANNES; COENEN HEINRICH HUBERT
权利人:WAGNER FRANZISKA; ERMERT JOHANNES; COENEN HEINRICH HUBERT; FORSCHUNGSZENTRUM JUELICH GMBH
摘要:Disclosed is a method for producing precursors for 2-[ 18 F]fluorophenylalanine and 6-[ 18 F]fluoro-L-meta-tyrosine and the α-methylated derivatives thereof, to the precursor, and to a method for producing 2-[ 18 F]fluorophenylalanine and 6-[ 18 F]fluoro-L-meta-tyrosine and the α-methylated derivatives thereof from particular precursor. A compound of formula (3) is provided which enables an automated synthesis of L-3,4-dihydroxy-6-[ 18 F]fluorophenylalanine and 6-[ 18 F]fluoro-L-meta-tyrosine. The enantiomeric purity of the product is ≧98%.
专利号:US-9751874-B2
优先权日:2014-12-17
标题:Hydroxy containing FXR (NR1H4) modulating compounds
发明人:GEGE CHRISTIAN; KINZEL OLAF; KREMOSER CLAUS; SCHMITT AARON C
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.