专利号:US-7655445-B2 优先权日:2003-11-12 标题 :Methods for synthesis of sulfated saccharides 发明人:ROSENBERG ROBERT D; BALAGURUNATHAN KUBERAN 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The present invention provides methods, processes and reaction mixtures, which produce sulfated heparosan polysaccharides. This invention also provides methods and reaction mixtures for the synthesis of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides.
专利号:US-2015031898-A1 优先权日:2012-03-09 标题 :Process for preparation of prostaglandin f2 alpha analogues 发明人:DAMS IWONA; KUTNER ANDRZEJ; CHODYNSKI MICHAL; KRUPA MALGORZATA; PIETRASZEK ANITA; ZEZULA MARTA; CMOCH PIOTR; KOSINSKA MONIKA 权利人:INST FARMACEUTYCZNY 摘要:A convergent synthesis of the prostaglandin F 2α analogues, travoprost and bimatoprost, was developed employing Julia-Lythgoe olefination of the structurally advanced phenylsulfone with an enantiomerically pure aldehyde ω-chain synthon. The novel convergent strategy allows the synthesis of a whole series of prostaglandin analogues of high purity from a common and structurally advanced prostaglandin intermediate.
专利号:US-2014349962-A1 优先权日:2013-05-24 标 题 :Rapid two-step synthesis of anti-coagulants 发明人:ROSENBERG ROBERT D; BALAGURUNATHAN KUBERAB 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The present invention provides methods for the production of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, compounds thus obtained and compositions comprising same. This invention also provides applications of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, and compositions comprising same, for use in controlling coagulation and treating thrombosis.
专利号:US-8846373-B2 优先权日:2011-07-29 标 题 :Methods of using a bacterial GlcNAc-6-P 2′- epimerase to promote sialylation of glycoconjugates 发明人:GEISLER CHRISTOPH; JARVIS DONALD 权利人:GEISLER CHRISTOPH; JARVIS DONALD; UNIV WYOMING 摘要:The present invention relates to new methods to promote sialylation of glycoconjugates, including recombinant glycoproteins, in glycoconjugate production systems. The invention relates to methods to promote efficient glycoconjugate sialylation in recombinant expression systems, by providing simpler and more economical ways to produce large intracellular pools of sialic acid precursors. The invention is directed to nucleic acids, vectors, and cells harboring vectors comprising nucleic acids encoding enzymes involved in the synthesis of sialic acid precursors, and cells harboring these nucleic acids in combination with nucleic acids encoding glycosyltransferases, including sialyltransferases, to facilitate the production of humanized recombinant glycoproteins in bacterial, fungal, plant, and animal cell expression systems. The engineered cells can be used to produce glycosylated proteins in virally-infected, transiently-transformed, or stably-transformed host cells, including lepidopteran insects and cultured cell lines derived from Spodoptera frugiperda, Trichoplusia ni , and Bombyx mori that can be infected by baculovirus expression vectors.
专利号:WO-9630508-A1 优先权日:1995-03-24 标 题:Assembly of complex molecular and supramolecular objects and devices and uses thereof 发明人:RABANI ELY MICHAEL 权利人:RABANI ELY MICHAEL 摘要:The present invention provides method and means for synthesis of components comprising affinity groups, structural members and optionally functional members into assemblages having well controlled structure on the molecular and atomic scale. Methods are provided for the hierarchial construction of components and assemblages thereof which expand assemblage structure in a well controlled manner while retaining controlled addressability of affinity groups through differentiation of the specificity of affinity groups. Methods for the immobilization of such components or assemblages thereof to solid phases, particles, surfaces, actuators and sensors in well controlled manners are provided. Additional methods and means for effecting the controlled colocalization of objects comprising the components of the present invention are provided. The present invention has broad applicability to several technologically and industrially critical applications, as demonstrated by specific embodiments of the present invention useful in diverse applications.
专利号:US-8374348-B2 优先权日:2002-01-18 标题:Device for secure transmission recording and visualisation of audiovisual programmes 发明人:LECOMTE DANIEL 权利人:NAGRA FRANCE; LECOMTE DANIEL 摘要:A method of distributing video sequences according to a nominal flow format including a succession of frames each including at least one I block corresponding to a complete digital I image and at least one N block corresponding to differences between a digital N image and at least one other image including analyzing the flow of sequences to generate a first modified flow having a format of a nominal flow and having modified N blocks and a second flow of any format including digital information required to reconstruct the modified blocks; and transmitting the first and second flows from a server to destination equipment, and calculating on the destination equipment a synthesis of a flow in a nominal format as a function of the first flow and the second flow.
1: Wei S, Li P, Ji M, Dong Q, Wang H. Target-site resistance to bensulfuron-methyl in Sagittaria trifolia L. populations. Pestic Biochem Physiol. 2015 Oct;124:81-5. doi: 10.1016/j.pestbp.2015.05.001. Epub 2015 May 11. doi: 10.1007/s10532-012-9556-7. Epub 2012 May 22. doi: 10.1016/S1001-0742(13)60446-5. doi: 10.1016/j.jchromb.2015.05.008. Epub 2015 May 14. doi: 10.1007/s10646-012-0882-7. Epub 2012 Mar 20. Chinese. doi: 10.1007/s00244-010-9626-y. Epub 2010 Dec 3. doi: 10.1016/j.jhazmat.2008.02.115. Epub 2008 Mar 8. doi: 10.1021/jf803386v. Epub 2009 Apr 22. doi: 10.3389/fpls.2016.01970. eCollection 2016. 15: Lin X, Zhao Y, Fu Q, Umashankara ML, Feng Z. Analysis of culturable and unculturable microbial community in bensulfuron-methyl contaminated paddy soils. J Environ Sci (China). 2008;20(12):1494-500. doi: 10.1016/j.chemosphere.2011.02.055. Epub 2011 Apr 5. Chinese.
合成参考文献
参考文献:10.2116/analsci.22.835 摘要:Sasaki H, Yonekubo J, Hayakawa K. A new on-line sample preparation system for the liquid chromatography/time-of-flight mass spectrometry simultaneous analysis of pesticides in river water. Anal Sci. 2006 Jun;22(6):835–40. doi: 10.2116/analsci.22.835. 参考文献:10.1002/etc.582 摘要:Nagai T, Ishihara S, Yokoyama A, Iwafune T. Effects of four rice paddy herbicides on algal cell viability and the relationship with population recovery. Environ Toxicol Chem. 2011 Aug;30(8):1898–905. doi: 10.1002/etc.582. 参考文献:10.1016/j.pestbp.2015.05.001 摘要:Wei S, Li P, Ji M, Dong Q, Wang H. Target-site resistance to bensulfuron-methyl in Sagittaria trifolia L. populations. Pestic Biochem Physiol. 2015 Oct;124():81–5. doi: 10.1016/j.pestbp.2015.05.001. 参考文献:10.1007/s00604-019-3610-7 摘要:Chen L, Wu J, Huang X. Multiple monolithic fibers modified with a molecularly imprinted polymer for solid phase microextraction of sulfonylurea herbicides based on boron-nitrogen interaction. Mikrochim Acta. 2019 Jun 25;186(7):470. doi: 10.1007/s00604-019-3610-7.