CAS: 91591-63-8; 2,5-Dichloro-4,6-Dimethylnicotinonitrile

相似化合物

142266-66-8 175204-44-1 14237-71-9

上下游产品

5-chloro-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 3-Cyano-4,6-dimethyl-2(1H)-pyridon acetylacetone 2-hydroxy-4,6-dimethyl-3-carbonitrile 2,5-dichloro-4,6-dimethylnicotinamide 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide 5-[3-(2,5-dichloro-4,6-dimethyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene

3-氰基-4,6-二甲基-2-羟基吡啶置于磺酰氯,三氯氧磷体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 7.0H,反应生成 2,5-二氯-4,6-二甲基烟腈
参考文献:A Structure-activity Relationship Study Of The Positive Allosteric Modulator Ly2033298 At The M4 Muscarinic Acetylcholine Receptor
标题:A Structure-activity Relationship Study Of The Positive Allosteric Modulator Ly2033298 At The M4 Muscarinic Acetylcholine Receptor
摘要:靶向m4肌酸乙酰胆碱受体的阳性变构调节剂通过其新颖的作用方式,相较于传统的正交配体,提供更高的亚型选择性和作为中枢神经系统药物的独特潜力.
DOI:10.1039/c5Md00334B

专利信息

专利号:US-2018370958-A1
优先权日:2017-06-27
标题:Route Of Synthesis For Opicapone
发明人：NABOLD CHRISTIAN FRECH; AEBERSOLD CHRISTINE; GRIECO PASQUALE GABRIELE; AESCHBACHER ROMAN GERBER
权利人:AZAD PHARMACEUTICAL INGREDIENTS AG
摘要:The present invention relates to a new route of synthesis for obtaining Opicapone ((4Z)-4-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-2H-1,2,4-oxadia-zol-5-ylidene]-2-hydroxy-6-nitrocyclohexa-2,5-dien-1-one), new intermediates in the reaction path and the new substance 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidoyl chloride.

专利号:US-2016200733-A1
优先权日:2013-08-23
标 题 :Substituted thieno[2,3-b]pyridine-2-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; POSLUSNEY MICHAEL S; MELANCON BRUCE J
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted thieno[2,3-b]pyridine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:EP-3421456-A1
优先权日:2017-06-27
标题:New route of synthesis for opicapone

专利号:GB-2563858-A
优先权日:2017-06-27
标 题:New route of synthesis for opicapone