CAS: 1125-78-6; 5,6,7,8-Tetrahydro-2-Naphthol

该化合物是2-甲硫醇的氢化衍生物,具有部分饱和氯化萘环结构,该化合物因其稳定性增强和与母分子相比芳香性降低而得到估价,使其在精细化学合成和制药中间体中有用.其2级的氢化组允许进一步功能化,使在开发离心机,催化剂和特殊材料方面的应用得以应用.四氢改变可提高有机溶剂的溶解性,同时保持再活性,便利其在选择性转化中的使用.该化合物通常在惰性条件下处理,以保持其纯度和再活性特征.

结构式图片

相似化合物

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合成工艺路线路线简述

  • 合成目标产物 5,6,7,8-Tetrahydro-2-Naphthol 主要起始原料 6-Methoxy-1,2,3,4-Tetrahydronaphthalene
  • (文献来源)合成步骤主要原料 6-Methoxy-1,2,3,4-Tetrahydronaphthalene
1,2,3,4-四氢萘置于硫酸体系中,化学反应生成5,6,7,8-四氢-2-萘酚
参考文献:De299603
标题:De299603

海关参考信息

专利信息


专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2008103618-A1
优先权日:2007-02-22
标 题 :Synthesis of novel xylosides and potential uses thereof

专利号:GB-2193211-A
优先权日:1986-08-01
标题 :Synthesis of benzofurans

专利号:UA-78297-C2
优先权日:2002-04-10
标 题:1- or 3-thiabenzonaphlhoazulene as inhibitors of tumour necrosis factor production and intermediates for synthesis thereof

专利号:US-7638554-B2
优先权日:2002-04-18
标题 :Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
发明人:WALEH NAHID; ZAVERI NURULAIN T
权利人:STANFORD RES INST INT
摘要:Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) n nwherein R 1 through R 3 and R 5 through R 11 are defined herein, and α, β and γ are optional bonds, providing that when α is absent, β is present, and when β is absent, α is present. When α is present, preferred R 4 moieties are selected from O, S, NH and CH 2 , and when α is absent, preferred R 4 groups are selected from OH, SH, NH 2 and CH 3 . When γ is present, the preferred R 5 substituent is O, while when γ is absent, the preferred R 5 substituent is OH. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

专利号:US-7329687-B2
优先权日:2002-04-18
标 题:Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents
发明人:ZAVERI NURULAIN; CHAO WAN-RU
权利人:STANFORD RES INST INT
摘要:Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) n nwherein R 1 through R 3 and R 5 through R 11 are defined herein, and α, β, and γ are optional bonds, providing that when α is absent, β is present, and when β is absent, α is present. When α is present, preferred R 4 moieties are selected from O, S, NH and CH 2 , and when α is absent, preferred R 4 groups are selected from OH, SH, NH 2 and CH 3 . When γ is present, the preferred R 5 substituent is O, while when γ is absent, the preferred R 5 substituent is OH. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.
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主要参考文献

参考标题:Diversity Oriented Clicking (Doc): Divergent Synthesis Of Sufexable Pharmacophores From 2‐substituted‐alkynyl‐1‐sulfonyl Fluoride (Sasf) Hubs
作者:Christopher J. Smedley,Gencheng Li,Andrew S. Barrow,Timothy L. Gialelis,Marie‐claire Giel,Alessandra Ottonello,Yunfei Cheng,Seiya Kitamura,Dennis W. Wolan,K. Barry Sharpless,John E. Moses |发布日期:2020.7.20
摘要:Diversity Oriented Clicking (Doc) Is A Unified Click‐approach For The Modular Synthesis Of Lead‐like Structures Through Application Of The Wide Family Of Click Transformations. Doc Evolved From The Concept Of Achieving "Diversity With Ease" , By Combining Classic C−c π‐bond Click Chemistry With Recent Developments In Connective Sufex‐technologies. We Showcase 2‐substituted‐alkynyl‐1‐sulfonyl Fluorides

合成参考文献


摘要:Herter, S.; Turner, N. J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 67.
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
摘要:Angelini, E.; Sarlah, D., Science of Synthesis: Dearomatizations, (2026) .
摘要:Cunha, J. C.; Dedeiras, B.; Negrão, A. C. R.; Marques, M. M. B., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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