CAS: 1334513-02-8; (S)-Isopropyl 2-(((S)-(Perfluorophenoxy)(Phenoxy)Phosphoryl)Amino)Propanoate

相似化合物

1337529-56-2 1627824-09-2 1256490-52-4

上下游产品

CAS号17788-07-7 pentafluorophen... | CAS号39613-92-8 D-丙氨酸异丙酯盐酸盐 | CAS号261909-49-3 N-(氯苯氧基氧化膦基)-L-... | CAS号771-61-9 五氟苯酚 | CAS号770-12-7 二氯化磷酸苯酯 | CAS号1190307-88-0 索非布韦

二氯磷酸苯酯置于三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 5.0H,反应生成N-[(S)-(2,3,4,5,6-五氟苯氧基)苯氧基磷酰基]-L-丙氨酸异丙酯
参考文献:一种前药化合物及其在治疗癌症方面的应用
标题:一种前药化合物及其在治疗癌症方面的应用
摘要:本发明提供了式(I)的化合物及其药物上可接受的盐或酯,及其药物组合物;以及将本发明的化合物,药物组合物用于抑制或调节酪氨酸激酶的活性,治疗由酪氨酸激酶介导的包括癌症在内的疾病症状或病症.

专利信息

专利号:US-2017218006-A1
优先权日:2014-07-31
标题 :Synthesis of Phosphoramidates
发明人：WILHELM THORSTEN; SPITZENSTÄTTER HANS-PETER; SCHÖNE OLGA; RICHTER FRANK; SCHREINER ERWIN
权利人:SANDOZ AG
摘要:A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof; the process comprising providing a mixture comprising a compound of formula (II) and a compound of formula (III) subjecting the mixture provided in a) to reaction conditions in the presence of one or more Lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (I).

专利号:US-10100075-B2
优先权日:2013-12-23
标 题:Process for the preparation of sofosbuvir
发明人：KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; VAKITI SRINIVAS; TIRUMALARAJU BHAVANISANKAR
权利人:MYLAN LABORATORIES LTD; MYLAN LABORATORIES LTD
摘要:The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of sofosbuvir.

专利号:US-10344009-B2
优先权日:2015-11-03
标题 :Process for the preparation of sofosbuvir
发明人：JAYACHANDRA SURESHBABU; KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; DEV VIKAS CHANDRA; KOTTOLLA SAIPRASAD; RAO POTLA VENKATA SRINIVASA; VAKITI SRINIVAS; MUGGU CHAITANYA; DANDALA SUBRAMANYAM
权利人:MYLAN LABORATORIES LTD
摘要:A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

专利号:EP-3174892-A1
优先权日:2014-07-31
标 题:Synthesis of phosphoramidates

专利号:US-2014309413-A1
优先权日:2013-03-11
标题 :Methods of stereoselective synthesis of substituted nucleoside analogs
发明人：ROSE PETER JAMISON; JUNG YOUNG CHUN; BLIGH CAVAN MCKEON; IBRAHIM SHEREEN; ANZALONE LUIGI; MILLER JR DAVID B; VAN ALSTEN JOHN GREGG; CURRAN TIMOTHY THOMAS
权利人:VERTEX PHARMA
摘要:The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives