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- InChIKey: GYBINGQBXROMRS-UHFFFAOYNA-J
- InChI=1S/C8H11NO8.4Na/c10-5(11)1-3(7(14)15)9-4(8(16)17)2-6(12)13;;;;/h3-4,9H,1-2H2,(H,10,11)(H,12,13)(H,14,15)(H,16,17);;;;/q;4*+1/p-4…
- 计算化学: 氢键受体数9.0氢键供体数1.0可旋转键数8.0
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3792-50-5 17833-53-3 17459-54-0海关参考信息
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2905130000-正丁醇
2905399002-1,4-丁二醇
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专利信息
专利号:US-2011263720-A1
优先权日:2010-03-09
标 题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same
发明人:PAISLEY STEVEN D; LEPREE JASON M; HAWI AMALE; ECKHOFF MICHAEL
权利人:PENWEST PHARMACEUTICALS CO
摘要:The present invention is directed to a method of synthesizing a compound of Formula I: n n n n n n n n n n the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.
专利号:WO-2011112679-A1
优先权日:2010-03-09
标题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same
专利号:SG-184787-A1
优先权日:2010-03-09
标题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same
专利号:US-12036300-B2
优先权日:2021-03-31
标题:Methods and compositions for improving skin
发明人:LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
权利人:OREAL
摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.
专利号:CA-2792520-A1
优先权日:2010-03-09
标 题:Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same
专利号:AU-2011224411-A1
优先权日:2010-03-09
标题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same