CAS: 19646-07-2; 2,4-Dichloro-5-Methoxypyrimidine

相似化合物

60703-46-0 280582-25-4 695-85-2

上下游产品

5-methoxyuracil 5-Methoxypyrimidine-2,4(1H,3H)-dione 2-Chloro-4-hydrazino-5-methoxy-pyrimidine 2-{[2-chloro-5-(methoxy)-4-pyrimidinyl]amino}benzamide 2-chloro-5-methoxypyrimidin-4-amine 4-[5-methoxy-2-(3-nitrophenyl)pyrimidin-4-yl]morpholine

5-甲氧基-2,4-二羟基嘧啶置于n,N-二甲基苯胺,三氯氧磷体系中,化学反应生成2,4-二氯-5-甲氧基嘧啶
参考文献:二肽基肽酶iv的嘧啶酮和嘧啶二酮抑制剂的设计与合成
标题:二肽基肽酶iv的嘧啶酮和嘧啶二酮抑制剂的设计与合成
摘要:描述了两类杂环二肽基肽酶iv(dpp-4)抑制剂嘧啶酮和嘧啶二酮的发现.单次口服剂量后,这些有效的,选择性的和非共价的抑制剂可在糖尿病动物模型中持续降低血浆dpp-4活性并降低血糖.选择化合物13A,27B和27J进行开发.
Doi:10.1021/jm101016W

专利信息

专利号:US-11891375-B2
优先权日:2021-07-26
标 题 :Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of Lemborexant using the intermediates
发明人：AKHATOU ABDESLAM; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

专利号:US-9828336-B2
优先权日:2012-02-17
标题:Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
发明人：MONIZ GEORGE ANTHONY; WILCOXEN ANNIE ZHU; BENAYOUD FARID; TANAKA TOSHIAKI; SORIMACHI KEIICHI
权利人:EISAI R&D MAN CO LTD
摘要:The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

专利号:US-2023092143-A1
优先权日:2021-07-26
标 题:Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of lemborexant using the intermediates

专利号:ES-2933074-B2
优先权日:2021-07-26
标 题 :SYNTHESIS PROCEDURE OF 2,4-DIMETHYLPYRIMIDIN-5-OL, NEW INTERMEDIATE OF SUCH PROCEDURE AND USE OF THE PRODUCT IN THE SYNTHESIS OF LEMBOREXANT

专利号:CN-104114524-B
优先权日:2012-02-17
标 题 :Methods and compounds for the synthesis of orexin-2 receptor antagonists

专利号:CN-105153044-A
优先权日:2015-09-15
标 题 :A kind of method for the one-pot synthesis of sulfadoxine of HPLC monitoring reaction progress