CAS: 2105-94-4; 4-Bromo-2-Fluorophenol

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3-fluoro-4-methoxyphenyl bromide 2-fluorophenol 4-amino-2-fluorophenol 3-fluorobromobenzene (4-bromo-2-fluoro-phenoxy)-acetic acid 4-bromo-1-(difluoromethoxy)-2-fluoro-benzene

4-溴苯酚置于溶剂黄146,Selectfluor,溶剂红 43体系中,用 水 用作溶剂,化学反应 6.0H,以68%的收率获得4-溴-2-氟苯酚
参考文献:一种苯酚类化合物邻位直接氟化的方法
标题:一种苯酚类化合物邻位直接氟化的方法
摘要:本发明涉及一种苯酚类化合物邻位直接氟化的方法,所述方法包括:式(1A)所示苯酚类化合物与氟化试剂在溶剂中,在光催化剂和光源的作用下于室温下进行反应,反应完全后反应混合物经分离纯化得到式(2A)所示氟化苯酚类化合物;本发明的有益效果主要体现在:本发明提供了一种有机光催化苯酚直接氟化的方法,操作过程简单,原料都已商品化容易得到,光催化剂廉价易得且环境友好,反应条件温和,位点选择性高,反应高效,只需一步便可制得氟化苯酚类衍生物.

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6010641-A
优先权日:1995-07-21
标题 :Liquid crystal polymer devices and materials
发明人：SAGE IAN C; BLACKWOOD KEITH M; VERRALL MARK A; COATES DAVID; BEATTIE DAVID R
权利人:SECR DEFENCE BRIT
摘要:Methods for loading and alignment of liquid crystal polymers in electro-optic and electro-active devices comprise in-situ polymerisation between substrates of monomer material in the presence of a cationic initiator. This allows for the synthesis of liquid crystal polymers containing polyether backbones.

专利号:US-11020399-B2
优先权日:2011-05-04
标 题:Intermediates useful in the synthesis of compounds as modulators of protein kinases

专利号:US-6017926-A
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：ASKEW BEN C; COLEMAN PAUL J; DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; MEISSNER ROBERT S; PATANE MICHAEL A; WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

专利号:CN-107628932-B
优先权日:2017-10-30
标 题 :A kind of side fluorine-containing diphenylacetylene diluent for high birefringence liquid crystal and its synthesis method