CAS: 32084-59-6; 6-Bromoquinazolin-4-Ol

上下游产品

CAS号5794-88-7 2-氨基-5-溴苯甲酸 | CAS号77287-34-4 甲亚胺酸 | CAS号491-36-1 4-Quinazolinone | CAS号39263-32-6 2-氨基-5-溴代苯甲腈 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号6313-33-3 甲脒盐酸盐 | CAS号16313-66-9 2-氨基-5-溴苯甲酰胺 | CAS号149-73-5 原甲酸三甲酯 | CAS号64-18-6 甲酸 | CAS号38267-96-8 6-溴-4-氯喹唑啉 | CAS号491-36-1 4-Quinazolinone | CAS号57573-59-8 6-溴-3-甲基喹唑啉-4(3H)-酮 | CAS号100954-32-3 3-benzyl-6-brom... | CAS号307538-52-9 6-溴-4-(4-吗啉)喹唑啉 | CAS号206190-28-5 6-苯基-4(3H)-喹唑啉酮 | CAS号92103-93-0 6-溴-3-苯基-4(3h)-喹唑啉酮

5-溴靛红酸酐置于甲脒体系中,化学反应 2.0H,以89%的收率获得产物6-溴-4-羟基喹唑啉
参考文献:一种治疗乳腺癌药物的制备方法
标题:一种治疗乳腺癌药物的制备方法
摘要:本发明提供了一种治疗乳腺癌药物的制备方法,具体地,本发明涉及一种制备n‑{3‑氯‑4‑[(3‑氟苄基)甲氧基]苯基}‑6‑[5‑({[2‑(甲磺酰基)乙基]氨基}甲基)呋喃‑2‑基]‑4‑喹唑啉胺(ⅰ)的新方法.该方法以干净易得的5‑卤代靛红(ⅱ)为原料,通过氧化,取代,氯化,取代以及偶联步骤,合成目标产物(ⅰ).该方法具有起始原料干净易得,路线较短,操作简单,环境友好,原子经济性高,收率高,效果好等优点,因此适用于工业化生产.

专利信息

专利号:CN-111875549-A
优先权日:2020-08-11
标题 :A kind of method for photocatalytic synthesis of quinazolinone compound in water phase

专利号:US-8278322-B2
优先权日:2005-08-01
标题 :HCV NS3 protease inhibitors
发明人：HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B
权利人:HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:US-10202374-B2
优先权日:2014-02-27
标题 :6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors
发明人：VISHWAKARMA RAM ASREY; BHARATE SANDIP BIBISHAN; BHUSHAN SHASHI; YADAV RAMMOHAN RAO; GURU SANTOSH KUMAR; JOSHI PRASHANT
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R′ are as herein described. The present invention particularly relates to synthesis and anticancer and phoshpoinositide-3-kinase-α (PI3K-α) inhibitory activity. In addition, the invention relates to methods of using compounds for treating or preventing various cancers such as pancreatic, prostate, breast and melanoma.