CAS: 34097-60-4; Methyl Phenylsulfonylacetate

上下游产品

methanol benzenesulfonylacetic acid methyl 2-phenylsulfinylacetate methyl (phenylsulfanyl)acetate(E)-2-Benzenesulfonyl-deca-4,9-dienoic acid methyl ester (2E,6E)-9-Benzenesulfonyl-3,7-dimethyl-9-(2-methyl-propenyl)-deca-2,6-dienedioic acid dimethyl ester (2E,6E,10E)-13-Benzenesulfonyl-3,7,11-trimethyl-13-(2-methyl-propenyl)-tetradeca-2,6,10-trienedioic acid dimethyl ester (E)-1'-acetoxy-2'-penten-5'-yl-3-benzenesulfonyl-3-carbomethoxy-propanoate

(苯磺酰)乙酸置于2-氯-1-甲基吡啶碘化物体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 6.25H,反应生成 苯磺酰乙酸甲酯
参考文献:转换途径:室温中性溶剂分解和酰胺取代
标题:转换途径:室温中性溶剂分解和酰胺取代
摘要:粘连或扭曲:通过在氮原子上引入位阻,可以形成带有吸电子α取代基(z = Ar,Phso 2,P(o)(or)2,Cn或co 2 R)的稳定的线性酰胺.通过消除-加成机理诱导其经历溶剂分解和取代反应(见图).该过程的关键是绕酰胺键和α取代基z旋转的低障碍.
DOI:10.1002/anie.201107117

专利信息

专利号:US-6232471-B1
优先权日:1998-11-23
标 题:Synthesis of anti-inflammatory [1,2,3]triazoles
发明人：MAEHR HUBERT
权利人:HOFFMANN LA ROCHE
摘要:This invention relates to new processes for manufacturing 4-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methyl-3H-[1,2,3]triazole-5-carboxamide (compound I) as well as the following new intermediates useful in these synthetic processes. 2-benzenesulfonyl-N-methylacetamide (compound IV), 2-(benzenesulfonyl)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methylacrylamide (compound II) and threo-2-[2-benzenesulfonyl-1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[(methylcarbamoyl)ethyl]]-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methyl-2H-[1,2,3]triazole-4-carboxamide (compound III).

专利号:WO-0031052-A1
优先权日:1998-11-23
标 题 :Synthesis of anti-inflammatory [1,2,3]triazoles

专利号:CN-109942560-B
优先权日:2013-11-04
标 题 :Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B

专利号:CN-109942560-A
优先权日:2013-11-04
标题 :Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b

专利号:CN-114716453-A
优先权日:2013-11-04
标 题 :Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B