CAS: 420-16-6; Boron Trifluoride Acetonitrile Complex

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CAS号7637-07-2 三氟化硼 | CAS号75-05-8 乙腈

三氟化硼,乙腈 反应生成 三氟化硼乙腈
参考文献:改善有机可溶性二氟氯酸盐和四氟氯酸盐 (I)/(Iii) 盐的获取.
标题:改善有机可溶性二氟氯酸盐和四氟氯酸盐 (I)/(Iii) 盐的获取.
摘要:描述了四氟化氯酸四烷基铵(Iii) [cat][clf 4] ([cat]=[net 3 Me] +,[net 4] +)的简易一锅克级合成.相应的烷基氯化铵盐的乙腈溶液在低温下用稀氟进行氟化.该反应通过[clf 2]-阴离子进行,该阴离子的结构首次得到表征.[clf 4]-盐作为氟化剂的潜在应用通过与二苯基二硫化物 Ph 2 S 2反应反应生成五氟硫基苯 Phsf 5进行评估.乙腈和[b(Cn) 4]-中的cn部分转移至cf 3基团中.暴露于一氧化碳(co)会导致碳酰氟(cof 2)的形成,并且元素金在四氟化金酸盐[auf 4]-的形成下溶解.
DOI:10.1002/anie.202006268

专利信息

专利号:US-11976081-B2
优先权日:2019-04-26
标题 :Intermediate of eribulin and synthesis method and use thereof
发明人：XU WEIPING
权利人:BEIJING TIENYI LUFU PHARMATECH CO LTD
摘要:An intermediate compound is prepared and used for the synthesis of halichondrin B, eribulin or an analog thereof, particularly a structural fragment C27-C35 thereof. The starting materials of the synthetic route are readily available, and the optical purity of the starting materials can be ensured, so that the optical purity of the structural fragment C27-C35 in halichondrin B, eribulin or the analog thereof is ensured. Steps for constructing a chiral center of the structural fragment C27-C35 feature higher diastereoselectivity and yield, in particular preparation methods of compounds of formulae (X), (XI), (XVI) and (XV). By-products of partial reactions can be removed only by recrystallization, which results in easy purification and significant reduce in cost.

专利号:US-9982008-B2
优先权日:2012-06-19
标题 :Preparation and uses of obeticholic acid
发明人：STEINER ANDRÉ; WAENERLUND POULSEN HEIDI; JOLIBOIS EMILIE; REWOLINSKI MELISSA; GROSS RALF; SHARP EMMA; DUBAS-FISHER FIONA; EBERLIN ALEX
权利人:INTERCEPT PHARMACEUTICALS INC
摘要:The present invention relates to obeticholic acid: n nor a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.

专利号:WO-2025024449-A1
优先权日:2023-07-24
标 题:Processes and intermediates for synthesis of mrtx1133
发明人：GHARBAOUI TAWFIK; SCATTOLIN THOMAS; CHEN CHENG
权利人:MIRATI THERAPEUTICS INC
摘要:The present invention relates to new synthetic routes of synthesizing MRTX1133. The invention also provides intermediates used in the provided synthetic routes.

专利号:US-9284336-B1
优先权日:2014-08-21
标题 :Synthesis of 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate and analogs
发明人：LAALI KENNETH K
权利人:LAALI KENNETH K; UNIV NORTH FLORIDA
摘要:4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate salt was synthesized and isolated. The pentafluorosulfanyl salt was examined in a wide assortment of reactions to form novel SF 5 -bearing alkenes, alkynes, and biaryl derivatives using Heck-Matsuda, Sonogashira, and Suzuki coupling protocols. Dediazoniation of the salt furnished the corresponding p-SF 5 —C 6 H 4 X, C 6 H 4 OS(O)(CF 3 )â•?NSO 2 CF 3 , and p-SF 5 —C 6 H 4 —NTf 2 derivatives. The azide derivative p-SF 5 —C 6 H 4 N 3 entered into click chemistry with phenylacetylenes to furnish the corresponding triazoles. Various SF 5 -bearing alkenes were synthesized by coupling reactions using a metal catalyst. Fluorodediazoniation selectively furnished the fluoro derivative p-SF 5 —C 6 H 4 F. Homolytic dediazoniation gave the unsymmetrical biaryls, thus demonstrating the broad utility of pentafluorosulfanyl diazonium salts as building blocks of SF5-aromatics that are in high demand in many branches of chemistry including biomedicine and materials chemistry.

专利号:US-9732116-B2
优先权日:2012-06-19
标 题 :Preparation and uses of obeticholic acid
发明人：STEINER ANDRÉ; WAENERLUND POULSEN HEIDI; JOLIBOIS EMILIE; REWOLINSKI MELISSA; GROSS RALF; SHARP EMMA; DUBAS-FISHER FIONA; EBERLIN ALEX
权利人:INTERCEPT PHARMACEUTICALS INC
摘要:The present invention relates to obeticholic acid: n nor a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.

专利号:CN-204727810-U
优先权日:2015-06-11
标 题 :A recovery and refining device for acetonitrile in the synthesis of ceftriaxone sodium