CAS: 5932-53-6; (1R,5R,6S)-Rel-6-Hydroxy-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-One

主要参考文献

参考标题:Two-Carbon Bridge Substituted Cocaines: Enantioselective Synthesis, Attribution Of The Absolute Configuration And Biological Activity Of Novel 6- And 7-Methoxylated Cocaines
作者:Daniele Simoni,Marinella Roberti,Vincenza Andrisano,Monica Manferdini,Riccardo Rondanin,Francesco Paolo Invidiata |发布日期:1999.5
摘要:Structure-Activity Relationships Of Cocaine With The Aim To Elucidate Those Structural Features That Might Confer Antagonistic Properties To Such Analogues, We Describe Herein Our Synthetic Efforts To Prepare Two-Carbon Bridge Functionalized (Methoxylated And Hydroxylated) Analogues. Our Approach Makes Use Of A Modification Of The Classical Willstatter Synthesis Of Cocaine: Mannich Type Cyclization Of Acetonedicarboxylic

合成参考文献

参考文献:10.1177/1087057116635503
摘要:Voter AF, Manthei KA, Keck JL. A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. J Biomol Screen. 2016 Jul;21(6):626–33.