CAS: 73-67-6; (4-Amino-2-Methyl-5-Pyrimidinyl)Methanol

上下游产品

water Aneurin 5-(2,4-dinitro-phenoxymethyl)-2-methyl-pyrimidin-4-ylamine 5-bromomethyl-2-methyl-pyrimidin-4-ylamine 5-(chloromethyl)-2-methyl-pyrimidin-4-amine thiamine pyrophosphate

4-氨基-2-甲基嘧啶-5-甲醛置于sodium Tetrahydroborate体系中,用 甲醇 作为反应溶剂,化学反应 0.5H,以93%的收率获得产物4-氨基-5-羟基甲基-2-甲基嘧啶
参考文献:酵母中硫胺素的生物合成-作为前体的4-羟基-5-羟甲基-2-甲基嘧啶的评估
标题:酵母中硫胺素的生物合成-作为前体的4-羟基-5-羟甲基-2-甲基嘧啶的评估
摘要:4-羟基-5-羟甲基-2-甲基嘧啶的推定作用2中的硫胺生物合成后期的前体1由酿酒酵母一直使用氘代衍生物检查2A中.为了能够测量氘掺入1的嘧啶环片段中,已经开发了使用来自解氨化芽孢杆菌的硫胺素i将1降解为苯胺衍生物6的方法.虽然将4-氨基-2-甲基-5-羟基[2 H 1]甲基嘧啶3A掺入硫胺素中,但氘是由羟基嘧啶制成的2A未明显结合,表明化合物2的胺化不是嘧啶环生物合成的后期步骤.
DOI:10.1039/p19900002963

专利信息

专利号:US-10717759-B2
优先权日:2013-09-17
标题 :Non-enzymatic, salt-mediated synthesis of polynucleic acids
发明人：DEAMER DAVID W; MAUREL MARIE-CHRISTINE; DA SILVA LAURA
权利人:UNIV CALIFORNIA; UNIV SORBONNE
摘要:Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid polymerase and lipids, but containing mononucleotides and a monovalent salt; (b) drying and resolubilizing the mixture of step (a) a plurality of times; and (c) recovering polynucleic acids from a resolubilized mixture of step (b). In certain aspects, the method further uses a low pH, e.g. about 3; it can utilize monophosphates, such as AMP rather than ATP; and it can be used with a polynucleotide template to form a sequence at least partially complementary to said template. Thus, both single-stranded and double-stranded polynucleic acids are provided. Ammonia salts have been used to obtain RNA lengths from 10 to 300 nucleotides after 16 half hour cycles and an effective temperature includes between 80° C. and 100° C.

专利号:TW-I655905-B
优先权日:2012-07-24
标题 :Contains 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof and very long chain fatty acid (VLCFA) Synthesis of herbicidal compositions with fatty acid/fat synthesis inhibiting herbicides

专利号:US-2005287169-A1
优先权日:2003-06-17
标 题 :Methods of use of genes of pyridoxal 5'-phosphate biosynthesis in Bacillus subtilis: avirulent strains for vaccines, and methods for identification of antibacterial agents
发明人：BELITSKY BORIS R
权利人:BELITSKY BORIS R
摘要:Methods and compositions comprising a pathogenic bacterial strain having a non-reverting mutation in a pdx gene encoding an enzyme involved in pyridoxal-5′-phosphate synthesis are provided, for use in vaccines, and methods for identification of inhibitors of the enzyme for use as an antibacterial agent are provided.

专利号:US-2019309011-A1
优先权日:2013-09-17
标 题 :Non-enzymatic, salt-mediated synthesis of polynucleic acids

专利号:CA-2708143-A1
优先权日:2007-12-07
标题 :Intermediates in the synthesis of zearalenone macrolide analogs

专利号:CA-2787919-A1
优先权日:2010-01-26
标题 :Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs