专利号:US-2015245570-A1 优先权日:2012-11-15 标题:Reverse synthesis of breeding lines 发明人:VOGELAAR ARIE; VERHOEF RUDOLF; SCHUT JOHANNES WILHELMUS; DIRKS ROBERT HÉLÈNE GHISLAIN 权利人:RIJK ZWAAN ZAADTEELT EN ZAADHANDEL BV 摘要:The invention relates to a method for producing parental lines for a hybrid organism. This method is based on the segregation of individual alleles in the spores produced by a desired plant and/or in the progeny derived from the self-pollination of that desired plant, and on the subsequent identification of suitable progeny plants in one generation, or in a limited number of inbred cycles. The invention further relates to a method for reconstructing a partially heterozygous starting organism.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:WO-2023239761-A1 优先权日:2022-06-07 标 题:Synthesis of a s-methoprene derivative 's-methobutene' with enhanced bioactivity against dipteran insects 发明人:SU HENG; SU TIANYUN 权利人:SU HENG; SU TIANYUN 摘要:Mosquitoes and mosquito-borne illness remain to significantly impact public health and human well-being nowadays. Mitigation by pesticides against larvae and adults has played a critical role in mosquito management. Larviciding is more cost effective than adulticiding in mosquito control operations. However, mosquito larvicides are historically low for numerous reasons. Currently larvicides with microbial and insect growth regulators (IGRs) account for most of the available products. Screening of new active ingredients (Als) or improvement of existing Als is desired to augment the arsenals for mosquito control. S-methoprene has been one of the main targets for research and development. The efficacy and safety of S-methoprene has been well documented since the late 1960s, and numerous products have been commercialized to combat pests of economic importance.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-10202620-B2 优先权日:2014-05-16 标 题:Synthesis of olefinic alcohols via enzymatic terminal hydroxylation 发明人:COELHO PEDRO; CHEN MIKE M Y; MEINHOLD PETER; CHO CATHERINE MEE-HIE; BUI VU; HEEL THOMAS 权利人:PROVIVI INC 摘要:In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.
专利号:US-12344573-B2 优先权日:2018-07-16 标题:Synthesis of straight-chain lepidopteran pheromones through one- or two-carbon homologation of fatty alkenes 发明人:WAMPLER KEITH M; LEE CHOON WOO; ROZZELL DAVID 权利人:PROVIVI INC 摘要:Methods for the preparation of alkenes including insect pheromones are described. The methods include homologation reactions employing reagents such as 1,3-diesters, epoxides, cyanoacetates, and cyanide salts for elongation of starting materials and intermediates by one or two carbon atoms. The alkenes include insect pheromones useful in a number of agricultural applications.
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合成参考文献
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