CAS: 39906-04-2; 4,6-Dichloro-2-Methylpyrimidin-5-Amine

相似化合物

13162-43-1 20090-59-9 5413-85-4

上下游产品

H-pyrimidin-4-one5-amino-6-chloro-2-methyl-3H-pyrimidin-4-one 4,6-dichloro-2-methyl-5-nitropyrimidine H-pyrimidine-4,6-dione2-methyl-5-nitro-1H-pyrimidine-4,6-dione 2-methyl-1H-pyrimidine-4,6-dione 5-amino-4-methoxy-6-chloro-2-methyl-pyrimidine 4-phenylpyrimidine-4,5-diamine6-chloro-2-methyl-N4-phenylpyrimidine-4,5-diamine 4-chloro-5-cyano-1,2,3-triazole -6-chloro-2-methylpyrimidine-4,5-diamine4-N-2-bromo-4-(1-methylethyl)phenyl-6-chloro-2-methylpyrimidine-4,5-diamine

2-甲基-4,6-二羟基嘧啶置于盐酸,硝酸,铁粉,溶剂黄146,N,N-二乙基苯胺,三氯氧磷体系中,用 甲醇,水 用作溶剂,化学反应 10.0H,反应生成2-甲基-4,6-二氯-5-氨基嘧啶
参考文献:苯基和二芳基脲与噻唑并 [5,4-D] 嘧啶支架作为血管生成抑制剂:设计,合成和生物学评价
标题:苯基和二芳基脲与噻唑并 [5,4-D] 嘧啶支架作为血管生成抑制剂:设计,合成和生物学评价
摘要:血管生成对肿瘤生长至关重要,抑制血管生成已被视为癌症治疗的一种有前途的方法.血管内皮生长因子受体-2 (Vegfr-2) 是血管生成的重要因素.在这项工作中,合理设计和合成了一系列抑制血管生成的新型噻唑并[5,4-D]嘧啶衍生物.在体外研究了它们对人脐静脉内皮细胞 (Huvec) 的抑制活性.1-(4-氟苯基)-3-{4-[(5-甲基-2-苯基[1,3]噻唑并[5,4-D]嘧啶-7-基)氨基]苯基}脲(19B)和1-(3-氟苯基)-3-{4-[(5-Methyl-2-Phenyl[1,3]Thiazolo[5,4-D]Pyrimidin-7-yl)Amino]Phenyl}Urea (19G)对 Huvec 增殖最有效的抑制作用(ic50 分别为 12.8 和 5.3 μm).化合物19G可抑制人脐静脉内皮细胞的迁移.这些结果支持进一步研究这些化合物作为有效的抗癌剂.
Doi:10.1002/cbdv.201800493

专利信息

专利号:US-9469614-B2
优先权日:2011-10-27
标 题:Synthesis of triazolopyrimidine compounds
发明人：ZUPANCIC BORUT; MARAS NENAD; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.

专利号:US-9278972-B2
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds
发明人：MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-9221829-B2
优先权日:2011-09-14
标题:Synthesis of triazolopyrimidine compounds
发明人：MARAS NENED; ZUPANCIC BORUT
权利人:MARAS NENED; ZUPANCIC BORUT; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of Ticagrelor (TCG).

专利号:US-2015005498-A1
优先权日:2011-09-14
标 题 :Synthesis of Triazolopyrimidine Compounds

专利号:US-2014371449-A1
优先权日:2011-12-23
标题 :Synthesis of Triazolopyrimidine Compounds

专利号:US-2014256747-A1
优先权日:2011-10-27
标 题 :Synthesis of Triazolopyrimidine Compounds