CAS: 541-88-8; Chloroacetic Anhydride

上下游产品

4-methyleneoxetan-2-one chloroacetic acid tetrakis(chloroacetoxy)silane sodium mon°Chloroacetic acid2-chloro-N-(6-chlorobenzo[d]thiazol-2-yl)acetamide 2-chloro-N-(6-ethoxy-1,3-benzothiazol-2-yl)acetamide 4-(chloroacetyl)antipyrine 1-(9H-carbazol-9-yl)-2-chloro-1-ethanone

氯乙酸置于n,N'-二环己基碳二亚胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 0.5H,反应生成 氯乙酸酐
参考文献:对grb2-Sh2域的非磷酸化环肽拮抗剂的构象约束的全局优化.
标题:对grb2-Sh2域的非磷酸化环肽拮抗剂的构象约束的全局优化.
摘要:继我们之前对噬菌体文库衍生的grb2 Sh2域的非磷酸化硫醚环化肽抑制剂的研究之后,设计并合成了一系列具有各种环化键或各种环大小的小肽类似物,并对其进行了评估,以研究对此的最佳构象约束新型grb2-Sh2阻滞剂.我们以前的sar研究表明,在此先导肽cyclo(ch(2)co-Glu(1)-Leu-Tyr-Glu-Asn中,约束构象以及除leu(2)和gly(7)外的所有氨基酸-Val-Gly-Met-Tyr-Cys(10))-酰胺(称为g1Te)对于维持生物活性是必需的.在这项研究中,为了尝试以最小的序列衍生出有效且可生物利用的grb2-Sh2抑制剂,我们通过优化环键对这种非磷酸化的环状配体进行了系统的构象研究,环的配置和环的大小.在假定活性构象时,暗示环化键的极性和构型很重要.将g1Te中的柔性硫醚键更改为相对刚性的亚砜键,可确保将效力提高4倍(4,Ic(50)= 6.5 Microm)
DOI:10.1016/s0968-0896(03)00411-5

专利信息

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6846917-B2
优先权日:2001-01-23
标题:Solid- and solution-phase synthesis of heparin and other glycosaminoglycans
发明人：SEEBERGER PETER H; ORGUEIRA HERNAN; SCHELL PETER
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides the basis for the preparation of combinatorial libraries and parallel libraries of defined glycosaminoglycan oligosaccharides. The defined glycosaminoglycan structures may be used in high-throughput screening experiments to identify carbohydrate sequences that regulate a host of recognition and signal-transduction processes. The determination of specific sequences involved in receptor binding holds great promise for the development of molecular tools which will allow modulation of processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. Notably, the present invention enables the automated synthesis of glycosaminoglycans in much the same fashion that peptides and oligonucleotides are currently assembled.

专利号:US-5488131-A
优先权日:1994-03-23
标题:Synthesis of compounds with predetermined chirality
发明人：MYERS ANDREW G
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98%, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.