CAS: 656247-18-6; (Z)-Methyl 3-(((4-(N-Methyl-2-(4-Methylpiperazin-1-yl)Acetamido)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindoline-6-Carboxylate Ethanesulfonate

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CAS号656247-17-5 尼达尼布 | CAS号594-45-6 乙基磺酸

(E)-Methyl 1-Acetyl-3-(Ethoxy(Phenyl)Methylene)-2-Oxoindoline-6-Carboxylate置于甲醇,Potassium Hydroxide体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 12.0H,反应生成 乙磺酸尼达尼布
参考文献:一种高纯度乙磺酸尼达尼布的制备方法
标题:一种高纯度乙磺酸尼达尼布的制备方法
摘要:本发明公开了一种高纯度乙磺酸尼达尼布的制备方法,所述方法,步骤如下:步骤1,甲苯,Sm01,原苯甲酸三乙酯,乙酸酐,Dmap"一锅法"反应,经抽滤即得高纯度中间体int02;步骤2,Int02,Sm02在特定溶剂体系中反应后分离得到中间体int03;步骤3,Int03,甲醇,Koh反应,得int04;步骤4,Int04,甲醇,乙磺酸反应,加入甲基叔丁醚,异丙醚,得乙磺酸尼达尼布.

专利信息

专利号:US-11261158-B2
优先权日:2017-11-17
标 题:Synthesis of 2-indolinone derivatives
发明人：PIISOLA ANTTI; TOIS JAN
权利人:FERMION OY
摘要:The present disclosure relates to a preparation method of methyl (E)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate from methyl 2-oxoindoline-6-carboxylate using high reaction temperatures and a reaction solvent enabling azeotropic removal of acetic acid during the reaction.

专利号:JP-2023171763-A
优先权日:2017-11-17
标 题:Synthesis of 2-indolinone derivatives known as intermediates for producing nintedanib

专利号:WO-2022061120-A1
优先权日:2020-09-18
标题 :Solid dispersions containing amorphous nintedanib, their synthesis and use thereof
发明人：ELLENBERGER DANIEL; MILLER DAVE
权利人:DISPERSOL TECHNOLOGIES LLC
摘要:The invention relates to solid dispersions containing amorphous nintedanib and methods making such solid dispersions. The invention also relates to pharmaceutical compositions containing such solid dispersions. The invention further relates to methods of making and administering such pharmaceutical compositions. The pharmaceutical compositions of the invention are useful in the treatment of oncological diseases, immunologic: diseases, or pathological conditions involving an immunologic component, or fibrotic diseases.

专利号:EP-3710427-B1
优先权日:2017-11-17
标题:Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib

专利号:CA-3082714-A1
优先权日:2017-11-17
标 题 :Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib

专利号:JP-7382317-B2
优先权日:2017-11-17
标题:Synthesis of 2-indolinone derivatives known as intermediates for producing nintedanib