CAS: 89531-58-8; 2-Morpholinoacetic Acid Hydrochloride

该化合物是一种多用途有机化合物,其特点是与乙酸酸协会相连的一角环,盐盐的形成增强了其稳定性和溶性.这种衍生物在制药和化学合成中特别宝贵,是生物活性分子发展的关键中间体.其结构特性有助于有效地融入更复杂的框架,使其在医药化学中有利于药物的发现和优化.盐化形式确保改善处理和储存特性.该化合物的再活性和纯度使其适合需要精确分子修改的应用,特别是在光伏分子药剂合成中.

英文名称2-Morpholinoacetic Acid Hydrochloride
中文名称4-吗啉乙酸盐酸盐
IUPAC名称2-morpholinoacetic acid hydrochloride
其它别名吗啉乙酸盐酸盐; 吗啉4乙酸盐酸盐; 2-Morpholinoacetic Acid Hydrochloride; 4-Morpholineacetic Acid Hydrochloride
CAS编号89531-58-8
MFCD编号:MFCD03540888
EINECS号:675-845-7
FDA UNII编号:PW689BJU3Z
分子式:C6H12ClNO3
分子量:181.62
产品CID: 1917068
产品分类有机原料→分子砌块→脂肪杂环类化合物→吗啉类化合物

相似结构搜索
InChIKey: ICGYBJNONRDZOP-UHFFFAOYSA-N
InChI=1S/C6H11NO3/c8-6(9)5-7-1-3-10-4-2-7/h1-5H2,(H,8,9)…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数2.0

相似化合物

3235-69-6 5807-02-3 3235-82-3

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼损伤类别1
严重眼刺激类别2
严重眼刺激类别2A
警示词Danger(危险)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36/37/39
危险类别码36-36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号3235-82-3 2-(4-吗啉基)乙酸乙酯 | CAS号110-91-8 吗啉 | CAS号105-36-2 溴乙酸乙酯 | CAS号88217-68-9 tert-butyl 2-mo...

合成工艺路线路线简述

105-39-5 = 89531-58-8
反应条件:1.1 Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 6 H,Reflux
标题:Synthesis And Antimicrobial Activities Of Some Quaternary Morpholinium Chlorides
作者:Brycki,Bogumil; Dega-Szafran,Zofia; Mirska,Ilona
参考文献:Polish Journal Of Microbiology 日期:2010 卷标:59(1) 页码:49-53]

105-36-2 = 89531-58-8
反应条件:1.1 Solvents: Diethyl Ether1.2 Reagents: Hydrochloric Acid1.3 Solvents: Methanol,Acetonitrile
标题:13C Cp Mas Nmr,Ftir,X-Ray Diffraction And Pm3 Studies Of Some N-(ω-Carboxyalkyl)Morpholine Hydrohalides
作者:Dega-Szafran,Z.; Gaszczyk,I.; Maciejewska,D.; Szafran,M.; Tykarska,E.; Et Al
参考文献:Journal Of Molecular Structure 日期:2001 卷标:560(1-3) 页码:261-273]

3235-82-3 = 89531-58-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,25 °C -> Reflux
标题:Tandem Palladium And Isothiourea Relay Catalysis: Enantioselective Synthesis Of α-Amino Acid Derivatives Via Allylic Amination And [2,3]-Sigmatropic Rearrangement
作者:Spoehrle,Stephanie S. M.; West,Thomas H.; Taylor,James E.; Slawin,Alexandra M. Z.; Smith,Andrew D.
参考文献:Journal Of The American Chemical Society 日期:2017 卷标:139(34) 页码:11895-11902]

105-36-2 = 89531-58-8
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; 3 H,Rt -> Reflux; Reflux -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 1 - 3 H,Reflux
标题:Synthesis Of A Gemcitabine Prodrug For Remote Loading Into Liposomes And Improved Therapeutic Effect
作者:May,Jonathan P.; Undzys,Elijus; Roy,Aniruddha; Li,Shyh-Dar
参考文献:Bioconjugate Chemistry 日期:2016 卷标:27(1) 页码:226-237]

3235-82-3 = 89531-58-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Rt -> Reflux
标题:Chiral N,N'-Dioxide/mg(Otf)2 Complex-Catalyzed Asymmetric [2,3]-Rearrangement Of In Situ Generated Ammonium Salts
作者:Lin,Qianchi; Hu,Bowen; Xu,Xi; Dong,Shunxi; Liu,Xiaohua; Et Al
参考文献:Chemical Science 日期:2020 卷标:11(11) 页码:3068-3073]

88217-68-9 = 89531-58-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Overnight,Rt
标题:Optimization Of Plasmepsin Inhibitor By Focusing On Similar Structural Feature With Chloroquine To Avoid Drug-Resistant Mechanism Of Plasmodium Falciparum
作者:Miura,Takuya; Hidaka,Koushi; Azai,Yukiko; Kashimoto,Keisuke; Kawasaki,Yuko; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2014 卷标:24(7) 页码:1698-1701]

3235-82-3 = 89531-58-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 12 H,100 °C
标题:N,N'-Dialkylaminoalkylcarbonyl (Daac) Prodrugs And Aminoalkylcarbonyl (Aac) Prodrugs Of 4-Hydroxyacetanilide And Naltrexone With Improved Skin Permeation Properties
作者:Devarajan-Ketha,H.; Sloan,K. B.
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(13) 页码:4078-4082

2-吗啉乙酸叔丁酯置于盐酸体系中,用 1,4-二氧六环作为反应溶剂,化学反应 12.0H,以99%的收率获得产物4-吗啉乙酸盐酸盐
参考文献:Fused Imidazo-Piperidine Jak Inhibitor Compound
标题:Fused Imidazo-Piperidine Jak Inhibitor Compound
摘要:该发明提供了一个具有化学式1的化合物或其药用可接受的盐,可作为jak抑制剂.该发明还提供了该化合物的晶体形式,包含该化合物的药物组合物,使用该化合物治疗适用于jak抑制剂的疾病的方法,以及用于制备该化合物的过程和中间体.

海关参考信息

2909110000-乙醚
2912110000-甲醛
2912120000-乙醛
2915110000-甲酸
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2023250042-A1
优先权日:2020-09-29
标题 :Curcusone diterpenoids and uses thereof
发明人：DAI MINGJI; CUI CHENGSEN; CAI ZHONGJIAN; ADIBEKIAN ALEXANDER; DWYER BRENDAN
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present disclosure provides the first asymmetric total synthesis and target identification of the curcusone natural products. The novel convergent synthesis is built upon a cheap and abundant chiral pool molecule (8) and features a thermal [3,3]-sigmatropic rearrangement and an FeCl3-promoted global hydrolysis/adol condensation cascade to rapidly construct the critical cycloheptadienone core. By performing chemoproteomics with the alkyne probe 37, we identified the previously â€œundruggableâ€? oncogenic protein BRAT1 as a key cellular target of 1d. Furthermore, 1d inhibits BRAT1 in cancer cells, thereby reducing cancer cell migration, increasing susceptibility to DNA damage, and inducing chemosensitization to the approved drug etoposide. Compound 1d is the first known small-molecule inhibitor for BRAT1, a master regulator of the DDR and DNA repair. Composition matters and methods of uses are within the scope of this disclosure.

专利号:RU-2139873-C1
优先权日:1994-03-16
标题:Imidazodiazepines, method of their synthesis and drug