CAS: 117772-70-0; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-2-Ethyl-3,4,10-Trihydroxy-13-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3,5,6,8,10,12,14-Heptameth
该化合物是一种半合成大型抗生素,主要用于治疗各种细菌感染,主要用于治疗各种细菌感染,其特征是,对成腺阳性细菌和小乳性细菌的广谱活动,使其对呼吸道感染,皮肤感染和性传染疾病有效;亚氮色素的化学结构包括一个大型乳腺环,它有助于其行动机制,抑制细菌蛋白合成;乙酰二丙胺通常作为白到非白晶体粉,在水中溶解,有利于口服和静脉注射制剂的配方;二氢化物形式表明存在两种与氮色素分子相关的水分子,可影响其稳定性和溶性;亚氮色素的化学结构为人所熟知,因为它具有有利的药用药用性,包括长半衰期,允许其一次性地防止抗日间治疗课程,比其他抗生素更短.不过,所有使用的所有抗生素都应用于.
- 英文名称(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-2-Ethyl-3,4,10-Trihydroxy-13-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3,5,6,8,10,12,14-Heptameth
- 中文名称阿奇霉素二水合物
- IUPAC名称(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one dihydrate
- 其它别名Azithromycin Dihydrate [usp Monograph] ; Azithromycin Dihydrate, >= (Hplc) ; Aciphar ; Azitral ; 9-Deoxo-9A-Aza-9A-Methyl-9A-Homoerythromycin A Dihydrate ; Zenstavion ; Dihydrate, Azithromycin ; Azithromycin Dihydrate [orange Book] ; Azitrox ; Azatek ;
- CAS编号117772-70-0
- MFCD编号:MFCD01862248
- EINECS号:641-134-5
- FDA UNII编号:JTE4MNN1MD
- 分子式:C38H76N2O14
- 分子量:785.03
- 产品CID: 227374
- 同类组份化合物CAS83905-01-5 (free)90581-30-9 (HCl)90581-31-0 (2HCl)117772-70-0 (dihydrate)121470-24-4 (monohydrate)
- 产品分类原料药 → 抗生素类药物 → 其它抗生素类药
物理性质
- 熔点113-115 °C
- 沸点822.1 °C at 760mmHg
- 闪点451 °C
- 密度1.18g/cm3
- PH:D26 -41.4° (c = 1 in CHCl3)
- PSA:198.54
- LogP:1.71
- 折射率-47 ° (C=2, EtOH)
- 蒸汽压2.51E-31mmHg at 25°C
- 溶解性Soluble In DMSO At 20mg/mL. Also Soluble In Chloroform Or Ethylene Chloride
- 敏感性空气敏感
- 外观形态类白色粉末
- 储存条件室温
- 产品应用阿奇霉素二水合物(117772-70-0)的用途:本品可用于呼吸道感染,尿路感染,皮肤及软组织感染和性传播疾病.
MSDS等安全信息
欧盟法规
C&L通报上下游产品
azithromycin dihydrate Zithromax(R) water 9-Deoxo-9a-aza-9a-homoerythromycin Aazithromycin Monohydrate合成工艺路线路线简述
专利信息
专利号:WO-2004075874-A1
优先权日:2003-02-28
标题 :Method for treatment and prevention of acute and chronic pseudomonas aeruginosa airway infections with inhalable macrolides
发明人：MENEKSE OKTAY
权利人:ANBICS PATENTS LICENCES AG; MENEKSE OKTAY
摘要:Macrolides, in particular azalides such as azithromycin, are suited for the treatment or prevention of acute or chronic P. aeruginosa infections of the airways by inhalaÂtion. The mechanism of action is the inhibition of the quoÂrum sensing of P. aeruginosa, in particular the impediment of the las and rhl quorum sensing systems synthesis and the impediment of the synthesis of the autoinducers N-[3-oxodoÂ1o decanoyl]-L-homoserine lactone and N-butyrylhomoserine lacÂtone. This allows for inhalation treatments of P. aerugi-nosa infections at non-inhibiting concentrations of the macrolide.
专利号:CN-215963551-U
优先权日:2021-08-23
标 题 :A kind of cyclization reactor for azilsartan synthesis
网址: http://www.syntame.com
企业联系电话：0574-28802872👤
地址:宁波市鄞州区下应北路789号锐鼎加速器2号楼
企业联系电话：0574-28802872👤
📞宁波申泰生物科技有限公司 ⚠️参考联系方式
联系人：陈女士
电话：0574-28802872
传真：0574-28802872
邮箱：Info@syntame.com
通信地址: 宁波市鄞州区下应北路789号锐鼎加速器2号楼
邮编: 315105
电话：0574-28802872
传真：0574-28802872
邮箱：Info@syntame.com
通信地址: 宁波市鄞州区下应北路789号锐鼎加速器2号楼
邮编: 315105
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
地址:宁波市鄞州区下应北路789号锐鼎加速器2号楼
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。
第 1 / 1 页
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Bakheit AH, Al-Hadiya BM, Abd-Elgalil AA. Azithromycin. Profiles Drug Subst Excip Relat Methodol. 2014;39:1-40. doi: 10.1016/B978-0-12-800173-8.00001-5. Review. doi: 10.1136/bmjopen-2015-008194. Review.
3: Bin Abdulhak AA, Khan AR, Garbati MA, Qazi AH, Erwin P, Kisra S, Aly A, Farid T, El-Chami M, Wimmer AP. Azithromycin and Risk of Cardiovascular Death: A Meta-Analytic Review of Observational Studies. Am J Ther. 2015 Sep-Oct;22(5):e122-9. doi: 10.1097/MJT.0000000000000138. Review. e1-6. doi: 10.1016/j.amjmed.2015.07.032. Epub 2015 Aug 17. Review. doi: 10.3109/03639045.2014.931967. Epub 2014 Jul 1. doi: 10.1016/S0140-6736(12)60953-2. doi: 10.1002/pds.3842. Epub 2015 Aug 2. doi: 10.1093/jac/dku452. Epub 2014 Nov 21. doi: 10.1128/AAC.03951-14. Epub 2014 Nov 10.
10: Arnež M, Ružić-Sabljić E. Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans. Pediatr Infect Dis J. 2015 Oct;34(10):1045-8. doi: 10.1097/INF.0000000000000804. doi: 10.1002/jps.24084. Epub 2014 Aug 19. doi: 10.1128/AAC.02067-13. Epub 2013 Nov 4.
📝 需求与反馈
尽可能描述清楚需求与问题信息
