CAS: 122665-97-8; 4,4-Difluorocyclohexanecarboxylic Acid

相似化合物

178312-47-5 178312-48-6 265108-36-9

上下游产品

CAS号178312-47-5 4,4-二氟环己基甲酸乙酯 | CAS号17159-79-4 4-氧代环己甲酸乙酯 | CAS号810659-05-3 4,4-二氟环己基甲胺 | CAS号376348-65-1 马拉维若 | CAS号22419-35-8 4,4-二氟环己醇 | CAS号178312-48-6 (4,4-二氟环己基)甲醇 | CAS号121629-14-9 4,4-二氟环己烷甲酸甲酯 | CAS号927209-98-1 4,4-二氟环己甲酰胺 | CAS号376348-77-5 4,4-DIFLUORO-N-... | CAS号376348-75-3 4,4-二氟环己烷-1-甲酰氯

在 盐酸,水体系中,化学反应生成4,4-二氟环己甲酸
参考文献:Substituted Isoindolones And Their Use As Metabotropic Glutamate Receptor Potentiators
标题:Substituted Isoindolones And Their Use As Metabotropic Glutamate Receptor Potentiators
摘要:本发明涉及的是具有以下化学式i的化合物:其中r1,R2,R3,R4,R5,R6,R7,R8,R9和n的定义如描述中所定义的化合物.该发明还涉及制备这些化合物的过程,以及用于制备的新中间体,含有这些化合物的药物组合物,以及这些化合物在治疗中的使用.

专利信息

专利号:WO-2008132128-A3
优先权日:2007-04-27
标 题:Synthesis of a pharmaceutically active compound
发明人：WIESENHOEFER WOLFGANG; BUYLE OLIVIER; CALLENS ROLAND; GIRE ROMAN; POUSSET CYRILLE; JEANNIN LAURENT
权利人:SOLVAY; WIESENHOEFER WOLFGANG; BUYLE OLIVIER; CALLENS ROLAND; GIRE ROMAN; POUSSET CYRILLE; JEANNIN LAURENT
摘要:Process for the manufacture of UK- 427,857 ( Maraviroc ) which comprises a step wherein enantiopure (S)-3-amino-3-phenylpropan-1-ol is manufactured from a mixture of its enantiomers by crystallizing or precipitating from a solution containing the mixture of enantiomers of 3-amino-3-phenylpropan-1-ol, an enantiopure resolving agent and a solvent, a diastereomeric salt or complex of 3-amino-3-phenylpropan-1-ol with the resolving agent, said salt or complex being enriched in the (S)-enantiomer of 3-amino-3-phenylpropan-1-ol. Difluorocyclohexan oic acid derivatives useful in the process can be obtained by a process comprising subjecting an oxocyclohexanoic acid ester to reaction with an activated fluorocarboxylic acid derivative and fluorinating the obtained intermediate to obtain a difluorocyclo hexanoic acid ester.

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:EP-2989099-A1
优先权日:2013-04-26
标题 :A process for the synthesis of maraviroc

专利号:WO-2008132128-A2
优先权日:2007-04-27
标 题 :Synthesis of a pharmaceutically active compound

专利号:WO-2014173375-A1
优先权日:2013-04-26
标题 :A process for the synthesis of maraviroc

专利号:RU-2727723-C1
优先权日:2016-09-29
标 题 :Method for synthesis of novel chiral ligand, metal chelate, various unnatural amino acids, maraviroc and main intermediate compounds thereof