CAS: 19169-90-5; Bromomethylphenylsulfone

上下游产品

ethanol ((dibromomethyl)sulfonyl)benzene sodium ethanolate benzenesulfonylacetic acid1-phenylsulphonyl-3-methyl butane phenyl pentyl sulfone nonyl phenyl sulphone ((cyclohexylmethyl)sulfonyl)benzene

苯甲砜置于lithium Hexamethyldisilazane,溴体系中,用 1,4-二氧六环 用作溶剂,化学反应 3.5H,以56%的收率获得溴甲基苯基砜
参考文献:使用试剂-溶剂卤素键控制烷基砜的α-单-和α,α-二-卤代反应†
标题:使用试剂-溶剂卤素键控制烷基砜的α-单-和α,α-二-卤代反应†
摘要:烷基砜的直接和选择性α-单溴化是通过碱介导的亲电子卤化作用实现的.发现溶剂和亲电子溴源的适当组合对于控制所形成产品的性质至关重要,在此,提出了通过改变亲电子溴源的有效尺寸来控制试剂-溶剂卤素键来控制选择性的方法.相反,多卤化后,在后处理过程中进行选择性脱卤后,以高收率选择性地获得了α,α-二溴代砜.两种方法都可以以克为单位进行应用,并且单卤化成功地扩展到烷基砜的全选择性α-氯化,α-碘化和α-氟化.
Doi:10.1039/c9Cc00550A

专利信息

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人：LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

专利号:US-9428482-B2
优先权日:2011-01-27
标 题 :Process for synthesis of polyphenols
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE; SPHAERA PHARMA PTE LTD
摘要:The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.

专利号:JP-2020117531-A
优先权日:2013-01-26
标题 :Novel process for synthesis of catechins

专利号:US-2014031421-A1
优先权日:2011-01-27
标 题 :Novel process for synthesis of polyphenols

专利号:US-2015368223-A1
优先权日:2013-01-26
标 题 :Novel approach for synthesis of catechins