CAS: 230-27-3; Benzo[h]Quinoline

相似化合物

33155-90-7 1114904-98-1 605-88-9

上下游产品

CAS号134-32-7 1-萘胺 | CAS号504-63-2 1,3-丙二醇 | CAS号1097204-18-6 2-bromobenzo[h]... | CAS号181950-47-0 4-chlorobenzo[h... | CAS号202523-63-5 2-chlorobenzo[h... | CAS号17104-70-0 Benzo(h)quinoli... | CAS号6628-35-9 1-Propanol,3-(1... | CAS号64-17-5 乙醇 | CAS号201230-82-2 carbon monoxide | CAS号181950-47-0 4-chlorobenzo[h... | CAS号202523-63-5 2-chlorobenzo[h... | CAS号186268-22-4 9-nitrobenzo[h]... | CAS号218-34-8 Quinolino[8,7-h... | CAS号244-99-5 5H-茚并[1,2-b]吡啶 | CAS号33155-90-7 10-羟基苯并[ h] 喹啉 | CAS号83491-10-5 10-acetoxybenzo... | CAS号127664-00-0 5H-indeno[1,2-b...

7-溴-8-羟基喹啉置于sodium Hydroxide,碘代三甲硅烷,四乙基溴化铵,苯基锂体系中,用 四氢呋喃,二氯甲烷,水,乙腈 用作溶剂,化学反应生成7,8-苯并喹啉
参考文献:7,8-喹啉与呋喃二烯的生成及diels-Alder反应的研究
标题:7,8-喹啉与呋喃二烯的生成及diels-Alder反应的研究
摘要:适当的邻卤代甲苯磺酸盐前体与有机锂试剂的反应提供了通往中间体7,8-喹啉的第一个决定性途径.Diels-Alder与呋喃衍生物的反应证实了这种番石榴碱的瞬时存在,呋喃衍生物提供了内氧化物加合物.这些加合物的化学诱导重排使得能够以适度的收率进入10-羟基[ H ]苯并喹啉及其7-取代衍生物的关键化合物.
Doi:10.1016/j.Tetlet.2005.03.164

专利信息

专利号:US-10711138-B2
优先权日:2016-04-08
标题:Intermediates and procedures for the synthesis of functional materials
发明人：KIRSCH PEER; GUNST SUSANN
权利人:MERCK PATENT GMBH
摘要:The present invention relates to heteroaromatic compounds which have two different reactive groups, their use in the synthesis of asymmetrically substituted compounds, and synthesis processes in which the compounds according to the invention are reacted sequentially with two different compounds, whereby an asymmetrically substituted compound is formed.

专利号:US-8877930-B2
优先权日:2009-11-04
标 题 :Continuous flow synthesis of amino alcohols using microreactors
发明人：BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F
权利人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F; MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-8729310-B2
优先权日:2009-09-22
标题:Halogenated diarylamine compound and synthesis method thereof
发明人：OSAKA HARUE; INOUE HIROTO
权利人:OSAKA HARUE; INOUE HIROTO; SEMICONDUCTOR ENERGY LAB
摘要:An object is to provide a new halogenated diarylamine compound serving as a source material for synthesis of a variety of diarylamine compounds and triarylamine compounds and a synthesis method of the new halogenated diarylamine compound. A halogenated diarylamine compound represented by the following general formula (G1) and a synthesis method thereof are provided. Note that a variety of diarylamine compounds and triarylamine compounds can be synthesized using the halogenated diarylamine compound represented by the following general formula (G1).

专利号:US-8735391-B2
优先权日:2008-09-26
标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods
发明人：AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J
权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS
摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.