CAS: 27219-07-4; Boc-5-Ava-Oh

相似化合物

123622-48-0 660-88-8 23135-50-4

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号660-88-8 5-氨基戊酸 | CAS号74651-77-7 (E)-N-((tert-Bu... | CAS号85908-96-9 1-B°C-2-哌啶酮 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号41840-28-2 S-B°C-2-巯基-4,6-二甲基嘧啶 | CAS号497-19-8 纯碱 | CAS号675-20-7 2-氮己环酮 | CAS号51644-96-3 N-(5-氨基戊基)氨基甲酸叔丁酯 | CAS号83948-54-3 5-(t-B°C-氨基)-1-戊基溴化物 | CAS号660-88-8 5-氨基戊酸 | CAS号75178-90-4 5-(叔丁氧羰氨基)-1-戊醇 | CAS号2446-62-0 8,9-二氢-6H-吡啶并[2... | CAS号88313-82-0 S-(5-aminopenty... | CAS号91419-47-5 tert-butyl N-(5... | CAS号60811-47-4 2-chloro-6,7,8,...

1-Boc-2-哌啶酮置于lithium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应 0.5H,以90%的收率获得boc-5-氨基戊酸
参考文献:A Mild Two-Step Method For The Hydrolysis Of Lactams And Secondary Amides
标题:A Mild Two-Step Method For The Hydrolysis Of Lactams And Secondary Amides
摘要:
Doi:10.1021/jo00162A028

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2023295613-A1
优先权日:2020-02-14
标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
发明人：JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-11814621-B2
优先权日:2018-06-01
标题 :Expanding the chemical substrates for genetic code reprogramming
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; MOORE JEFFREY S; SCHWIETER KENNETH E; SCHWARZ KEVIN JEROME
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-8475998-B2
优先权日:2010-12-20
标 题 :Compound synthesis method, microarray, acid-transfer composition, and biochip composition
发明人：YUN HYOJIN; YOO CHANGEUN; KIM MYUNG-SUN; KIM SOO-KYUNG; NISHIKAWA KOUJI; GOTO HIROFUMI; MIYAMOTO HIDETOSHI
权利人:YUN HYOJIN; YOO CHANGEUN; KIM MYUNG-SUN; KIM SOO-KYUNG; NISHIKAWA KOUJI; GOTO HIROFUMI; MIYAMOTO HIDETOSHI; SAMSUNG ELECTRONICS CO LTD; JSR CORP
摘要:A compound synthesis method includes bonding a first compound to a substrate to form a first film. A second film is formed on the first film using an acid-transfer composition including (A) a polymer that includes a structural unit shown by a following formula (1) and a structural unit shown by a following formula (2), (B) a photoacid generator shown by a following formula (3), and (C) a sensitizer shown by a following formula (4). The second film is exposed to remove the protecting group from the first compound under an exposed area of the second film. An acid generated in the exposed area of the second film is transferred to the first film. The second film after being exposed is removed. A second compound is bonded to the first compound from which the protecting group has been removed.

专利号:US-5916899-A
优先权日:1996-10-18
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:US-6407103-B2
优先权日:1998-04-21
标 题:Indeno [1,2-c] pyrazol-4-ones and their uses
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.