CAS: 2861-28-1; 2-(Benzo[d][1,3]Dioxol-5-yl)Acetic Acid

上下游产品

CAS号326-59-0 苯并[1,3]二氧代l-5-乙酸甲酯 | CAS号62396-98-9 2-(苯并[d][1,3]二氧... | CAS号27738-46-1 3,4-(亚甲二氧基)苦杏仁酸 | CAS号26664-86-8 ethyl 2-(1,3-be... | CAS号6543-34-6 胡椒基甲醛 | CAS号79054-42-5 diethyl (E)-(2-... | CAS号94-59-7 黄樟素 | CAS号4439-02-5 3,4-亚甲二氧基苯乙腈 | CAS号102-32-9 3,4-二羟基苯乙酸 | CAS号25379-88-8 3,4-二羟基苯乙酸甲酯 | CAS号326-59-0 苯并[1,3]二氧代l-5-乙酸甲酯 | CAS号120-57-0 胡椒醛 | CAS号94-53-1 胡椒酸 | CAS号451-77-4 Homarylamine | CAS号51665-84-0 1,3-Benzodioxol... | CAS号197369-11-2 methyl 2-[6-(4-... | CAS号26664-86-8 ethyl 2-(1,3-be... | CAS号6006-82-2 3,4-亚甲二氧基苯乙醇 | CAS号621-37-4 3-羟基苯乙酸

3,4-二羟基苯乙酸置于硫酸,Cesium Fluoride体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 9.0H,反应生成胡椒乙酸
参考文献:多巴胺能(R)-和(S)-苄基四氢异喹啉的对映选择性合成.
标题:多巴胺能(R)-和(S)-苄基四氢异喹啉的对映选择性合成.
摘要:通过立体选择性还原以(R)-和(S)-苯基甘醇为基的异喹啉盐制备光学纯的(1S,R)-和(1R,S)-苄基四氢异喹啉(bthiqs)12A,B.手性辅助剂.通过单晶x射线分析明确地确定了(1S,R)-13A盐酸盐(来自12A的o-去苯甲酰化衍生物)和(1R,S)-12B非对映异构体的绝对构型.还原性除去手性辅助基团,随后的n-丙基化和亚甲二氧基的裂解提供了具有非常好总收率的旋光儿茶酚胺(1S)-16A和(1R)-16B.我们已经通过不对称合成中的经典方法首次单独制备了多巴胺能1-Bthiqs对映体对.(1S)-对映体(14A-16A)与d1和d2多巴胺受体结合,亲和力比相应的(1R)-对映体(14B-16B)高5-15倍.此外,(1S)-14A以高亲和力抑制[3H]多巴胺的摄取.看来,Bthiq(S)-对映异构体的合成和测试对于在多巴胺受体上寻找新的活性药物非常重要.
Doi:10.1021/jm001128U

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-8101804-B2
优先权日:2006-07-28
标 题 :Process for the synthesis of (E)-stilbene derivatives which makes it possible to obtain resveratrol and piceatannol
发明人：SCHOUTEETEN ALAIN; JUS SEBASTIEN; VALLEJOS JEAN-CLAUDE
权利人:SCHOUTEETEN ALAIN; JUS SEBASTIEN; VALLEJOS JEAN-CLAUDE; CLARIANT SPECIALTY FINE CHEM F
摘要:A subject-matter of the present invention is a novel process for the synthesis of (E)-stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol.

专利号:US-4003916-A
优先权日:1975-12-22
标 题:Total synthesis of steganacin and derivatives thereof
发明人：KENDE ANDREW S; LIEBESKIND LANNY S
权利人:KENDE ANDREW S; LIEBESKIND LANNY S
摘要:Steganacin and Steganangin, dibenzocyclooctadiene lignan lactones, have been reported to possess antileukemic activity. This invention describes the first total synthesis of these compounds and other relevant intermediates.

专利号:US-4059593-A
优先权日:1975-12-22
标 题:Synthesis of steganacin and derivatives thereof
发明人：KENDE ANDREW S; LIEBESKIND LANNY S
权利人:UNIV ROCHESTER
摘要:Steganacin and Steganangin, dibenzocyclooctadiene lignan lactones, have been reported to possess anti-leukemic activity. This invention describes the first total synthesis of these compounds and other relevant intermediates.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-7026339-B2
优先权日:2003-11-07
标题 :Inhibitors of HCV NS5B polymerase
发明人：YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
权利人:YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
摘要:The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.