CAS: 3634-56-8; Chloro-Dimethyl-Propan-2-Ylsilane

上下游产品

CAS号122420-34-2 异丙基二甲基甲氧基硅烷 | CAS号18209-92-2 isopropyl-dimet... | CAS号1068-55-9 异丙基氯化镁 | CAS号75-78-5 二甲基二氯硅烷 | CAS号7787-87-3 (1-氯乙基)三甲基硅烷 | CAS号4170-46-1 异丙基三氯硅烷 | CAS号917-54-4 甲基锂 | CAS号920-39-8 异丙基溴化镁 | CAS号75-29-6 2-氯丙烷 | CAS号7446-70-0 氯化铝 | CAS号3429-52-5 trimethyl-propa... | CAS号18209-61-5 二甲基异丙基硅烷

异丙基二甲基甲氧基硅烷置于盐酸体系中,用 Xylene 作为反应溶剂,化学反应 0.25H,以55%的收率获得产物二甲基异丙基氯硅烷
参考文献:由具有大取代基的烷氧基硅烷,硅烷醇和氢硅烷合成氯硅烷
标题:由具有大取代基的烷氧基硅烷,硅烷醇和氢硅烷合成氯硅烷
摘要:我们已经发现,商业上重要的三烷基氯硅烷可以通过烷氧基硅烷,硅烷醇和氢硅烷与浓盐酸水溶液的反应而容易地合成.带有庞大的烷基取代基的三烷基烷氧基硅烷的处理,例如i-Pr,仲-Bu,叔-Bu和环用35%盐酸水溶液的-Hex基团以优异的收率获得产物相应的三烷基氯硅烷.用35%的盐酸水溶液对三烷基硅烷醇进行类似的处理也以几乎定量的收率获得产物了三烷基氯硅烷.甲基三氯硅烷和二甲基二氯硅烷与带有庞大烷基的烷基格氏试剂反应,然后用浓盐酸水溶液处理所得混合物,以高收率生产了相应的二烷基甲基和烷基二甲基氯硅烷.在钯催化剂的存在下,用浓盐酸处理三烷基氢硅烷,可以高收率得到三烷基氯硅烷.
DOI:10.1016/j.Jorganchem.2005.08.028

专利信息

专利号:US-3992439-A
优先权日:1972-04-17
标 题:Synthesis of prostaglandins of the 'one'-series
发明人：SCHAAF THOMAS K; COREY ELIAS J
权利人:PFIZER
摘要:In the synthesis of prostaglandins of the 'one' -series an alteration in the conventional reaction sequence avoids side reactions and provides an improved synthesis via a series of novel intermediates. In this improved synthesis the side chain at the 8 position is attached to the five membered ring before the side chain at the 12 position is attached.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-7893283-B2
优先权日:2004-06-04
标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

专利号:US-5569762-A
优先权日:1994-01-14
标题:Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds
发明人：WISSNER ALLAN; TROVA MICHAEL P
权利人:AMERICAN CYANAMID CO
摘要:The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R 1 , R 50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.

专利号:WO-2008032104-A1
优先权日:2006-09-15
标题:One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：WALKER ROSS THOMSON; NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD; WALKER ROSS THOMSON; NAIDU RAGINA
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction, of protecting the C-10 and attaching a side chain at C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and intermediates used therein.

专利号:US-7202370-B2
优先权日:2003-10-27
标 题 :Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
发明人：NAIDU RAGINA
权利人:CONOR MEDSYSTEMS INC
摘要:A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.