CAS: 4702-13-0; N-Phthaloylglycine

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CAS号85-44-9 苯酐 | CAS号56-40-6 甘氨酸 | CAS号118-29-6 N-羟甲基邻苯二甲酰亚胺 | CAS号201230-82-2 carbon monoxide | CAS号6297-93-4 2-(1,3-二氧代异吲哚啉-... | CAS号3891-07-4 N-羟乙基酞酰亚胺 | CAS号5428-09-1 N-烯丙基邻苯二甲酰亚胺 | CAS号50-00-0 甲醛 | CAS号5332-26-3 N-(溴甲基)邻苯二甲酰亚胺 | CAS号3397-29-3 邻苯二甲酰甘氨酸羟基琥珀酰亚胺酯 | CAS号33512-26-4 邻苯二亚胺甲基磷酸二乙酯 | CAS号39221-42-6 (1-氧-1,3-二氢-异吲哚... | CAS号21313-49-5 邻苯二甲酰甘氨酸4-硝基苯酯 | CAS号2017-94-9 2-(1,3-dioxoiso... | CAS号19532-98-0 N1,N2-二甲基邻苯二甲酰胺 | CAS号550-44-7 N-甲基邻苯二甲酰亚胺 | CAS号2641-02-3 ethyl 2-[[2-(1,...

Isopropyl 2-(1,3-Dioxoisoindolin-2-yl)Acetate置于三氯化铝体系中,用 硝基甲烷 作为反应溶剂,化学反应 5.0H,以92%的收率获得产物邻苯二甲酰甘氨酸
参考文献:氯化铝对异丙酯,氨基甲酸酯和碳酸酯的选择性脱保护
标题:氯化铝对异丙酯,氨基甲酸酯和碳酸酯的选择性脱保护
摘要:异丙酯,氨基甲酸酯和碳酸酯的 O-异丙基键可在 0-50 °C,硝基甲烷中用 Alcl3 有效地选择性裂解,分别得到羧酸,胺和醇,收率从非常好到极佳.
DOI:10.1055/s-2001-17466

专利信息

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:WO-9946244-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2002165398-A1
优先权日:1998-03-12
标题:Modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimers disease and schizophrenia, and infectious diseases.

专利号:EP-1062204-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-3396157-A
优先权日:1964-12-01
标 题:Use of esters of nu, nu-dialkylhydroxylamines and 1-hydroxypiperidine for the synthesis of peptides and other amides
发明人：TYNDALE YOUNG GEOFFREY; ONSLOW HANDFORD BRIAN
权利人:NAT RES DEV

专利号:US-2722526-A
优先权日:1952-09-24
标题:Trialkylphosphites as acid acceptors in the synthesis of amides
发明人：WASHINGTON ANDERSON GEORGE; WILLIAM YOUNG RICHARD
权利人:AMERICAN CYANAMID CO