CAS: 593-71-5; Chloroiodomethane

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CAS号75-09-2 二氯甲烷 | CAS号75-11-6 二碘甲烷 | CAS号74-88-4 碘甲烷 | CAS号74-97-5 溴氯甲烷 | CAS号17305-95-2 chloro(chlorome... | CAS号874501-62-9 benzyl-chlorome... | CAS号10034-85-2 氢碘酸 | CAS号16519-98-5 iodomethane | CAS号33657-49-7 丁酸氯甲酯 | CAS号533-98-2 1,2-二溴丁烷 | CAS号5689-59-8 1-氯乙酰氨基金刚烷 | CAS号329685-40-7 3-苯基-1-丙基硼酸频哪酯 | CAS号33797-51-2 N,N-二甲基亚甲基碘化铵 | CAS号328-26-7 2-氯-N-(2-氯-5-(三... | CAS号534-07-6 1,3-二氯丙酮 | CAS号96-09-3 氧化苯乙烯 | CAS号98-85-1 苏合香醇

氯甲醇置于咪唑,碘,三苯基膦体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 氯碘甲烷
参考文献:可见光介导的 C-I 二氟烯丙基化,以 α-氨基烷基自由基为介体
标题:可见光介导的 C-I 二氟烯丙基化,以 α-氨基烷基自由基为介体
摘要:在此,我们报告了一种在室温下以 α-氨基烷基自由基为介质的 α-三氟甲基芳基烯烃与烷基碘的直接可见光介导的 C-I 二氟烯丙基化反应的方案.该协议允许使用环状和非环状伯,仲和叔烷基碘对各种 α-三氟甲基芳基烯烃进行有效功能化,并且可扩展到克级.这种温和的协议使用廉价的介质,适用于复杂天然产物和药物的后期功能化.
DOI:10.1021/acs.Orglett.1C02905

专利信息

专利号:US-4026911-A
优先权日:1976-02-23
标 题:Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2-(substituted)-cyclo-pentane-1,3,4-triones
发明人：REVERMAN LAWRENCE FRANCIS
权利人:MILES LAB
摘要:Reaction of a 2-methyl-2-(alkenyl)-1,3-dioxolane with an α,ω-dihalogenoalkane to obtain a 2-methyl-2-(ω-chloroalkynyl)-dioxolane, conversion of the latter to a corresponding nitrile, and hydrolysis of the nitrile to form a ketoalkynoic acid is a novel process for preparing the acid. n Use of the process in the synthesis of 2-(substituted)-cyclopentane-1,3,4-triones improves that synthesis.

专利号:US-7935837-B2
优先权日:2008-04-30
标 题:Process for synthesis of androstane 17-β carbothioic acid and relative compounds thereof
发明人：HSU NAI-HSUAN; PANG CHU-YI; WU CHIEN-JEN; HUANG CHI-JEN; HSU CHIA-JUNG; LEE PEIMIN
权利人:CORUM INC
摘要:A process for synthesis of androstane 17-β carbothioic acid is provided. The process includes mixing an androstane 17-β carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-β carbothioic acid, wherein the androstane 17-β carbothioic acid has the formula (I): n n n n n n n n n n n n wherein R 1 represents hydrogen or haloalkyl groups, R 2 represents C 1-8 linear alkyl groups, C 1-8 branched alkyl groups, C 1-6 unsaturated acyclic groups or aromatic groups, R 3 represents hydrogen or hydroxyl, R 4 represents hydrogen, bromine, chlorine or fluorine and R 5 represents hydrogen, bromine, chlorine or fluorine. The process is a one-pot reaction.

专利号:US-2025066296-A1
优先权日:2021-12-14
标题 :Methods for the synthesis of complement factor d inhibitors and intermediates thereof
发明人：HASHIMOTO AKIHIRO; PHADKE AVINASH; RAI U SANKAPPA; CHANDRAN PRABU
权利人:ALEXION PHARMA INC
摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-8927739-B2
优先权日:2011-05-18
标 题 :Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives
发明人：QIU YAO-LING; PENG XIAOWEN; KIM IN JONG; CAO HUI; TANG DATONG; OR YAT SUN; WANG GUOQIANG; XU GUOYOU
权利人:ENANTA PHARM INC
摘要:The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (Ia), (Ib) and (Ic):

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.