CAS: 610-96-8; Methyl 2-Chlorobenzoate

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CAS号67-56-1 甲醇 | CAS号17849-38-6 2-氯苄醇 | CAS号89-98-5 邻氯苯甲醛 | CAS号694-80-4 2-溴氯苯 | CAS号201230-82-2 carbon monoxide | CAS号95-50-1 邻二氯苯 | CAS号609-65-4 邻氯苯甲酰氯 | CAS号110-05-4 二叔丁基过氧化物 | CAS号118-91-2 邻氯苯甲酸 | CAS号1634-04-4 甲基叔丁基醚 | CAS号374538-03-1 2-(甲氧基羰基)苯硼酸 | CAS号4143-62-8 3',4'-二甲氧基黄酮 | CAS号344-96-7 2-(三氟甲基)苯甲酸甲酯 | CAS号133391-52-3 Methyl 2-pentaf... | CAS号4143-74-2 4'-甲氧基黄酮 | CAS号42074-68-0 2-氯三苯基氯甲烷 | CAS号4630-82-4 环己甲酸甲酯 | CAS号100-51-6 苯甲醇 | CAS号1769-24-0 2-甲基-4(1H)-喹唑啉酮 | CAS号40018-25-5 邻氯苯乙酰腈

2-氯苯甲酸置于吡啶,Disodium Hydrogenphosphate,草酰氯体系中,用 二氯甲烷,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 40.0H,反应生成 2-氯苯甲酸甲酯
参考文献:使用四甲基硼酸三甲基氧鎓将叔芳基酰胺直接温和转化为甲基酯:定向金属化反应的非常有用的补充
标题:使用四甲基硼酸三甲基氧鎓将叔芳基酰胺直接温和转化为甲基酯:定向金属化反应的非常有用的补充
摘要:研发了将叔酰胺直接转化为甲酯的直接方法的范围和一般性.该方法包括两步一锅法,其中首先用四氟硼酸三甲基氧鎓处理叔酰胺以反应生成亚氨酸酯中间体,然后通常通过加入饱和的碳酸氢钠水溶液将其水解.尽管该方法对于脂肪族酰胺是失败的,但是对于衍生自芳族羧酸的各种酰胺都实现了非常好的收率.在n-烷基上的立体位阻是很好的耐受性.因此,N,N-二甲基,-二乙基和-二异丙基酰胺均可被成功利用.
DOI:10.1016/s0040-4020(00)00969-8

专利信息

专利号:US-7951961-B2
优先权日:2006-07-07
标题:Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof
发明人：SIVAKUMAR MEENAKSHI; SHUKLA MANOJ; JADHAV PRAMOD KUMAR; BORHADE AJIT
权利人:PIRAMAL LIFE SCIENCES LTD
摘要:The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer n nwherein Ar has the meaning as indicated in the claims.

专利号:US-5780692-A
优先权日:1995-12-28
标 题:Process for producing optically active benzhydrol compounds
发明人：SAKAGUCHI MINZO; IMAI TAKASHI; MIURA TAKASHI; YAMAZAKI TETSURO
权利人:TAKASAGO PERFUMERY CO LTD
摘要:A process for producing a benzhydrol compound (II) which comprises hydrogenating a benzophenone compound (I) in the presence of a hydrogenation catalyst consisting of a transition metal complex, a base and an optically active diamine compound: (I) (II) wherein R1 to R10 each represents H, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 alkanoyl, etc., R2 and R3, and R8 and R9 may form -CH=CH-CH=CH-, or any two of R1 to R9 adjacent to each other may be bonded to thereby form -OCH2O- or -(CH2)3-. By using this process, optically active benzhydrol compounds which have a high purity and are useful as, for example, intermediates in the synthesis of drugs can be produced by simple procedures.

专利号:AU-2006346193-A2
优先权日:2006-07-07
标 题:An enantioselective synthesis of pyrrolidine-substituted flavones

专利号:AU-2006346193-C1
优先权日:2006-07-07
标题:An enantioselective synthesis of pyrrolidine-substituted flavones

专利号:AU-2006346193-B2
优先权日:2006-07-07
标题 :An enantioselective synthesis of pyrrolidine-substituted flavones

专利号:AU-2006346193-A1
优先权日:2006-07-07
标 题 :An enantioselective synthesis of pyrrolidine-substituted flavones