N-苄基-N-环丙基-N-甲胺置于palladium On Activated Charcoal 盐酸,氢气体系中,用 甲醇 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,反应 16.0H,以1.18 G的收率获得产物n-甲基环丙胺盐酸盐
参考文献:Mexab-Oprm Specific Efflux Pump Inhibitors In Pseudomonas Aeruginosa. Part 6: Exploration Of Aromatic Substituents
标题:Mexab-Oprm Specific Efflux Pump Inhibitors In Pseudomonas Aeruginosa. Part 6: Exploration Of Aromatic Substituents
摘要:A Series Of 4-Oxo-4H-Pyrido[1,2-A]Pyrimidine Derivatives,Derivatized At The 2-Position With Aromatic Substituents,Were Synthesized By The Suzuki Cross-Coupling Method And Evaluated For Their Ability To Potentiate The Activity Of The Fluoroquinolone Levofloxacin (Lvfx) And The Anti-Pseudomonas Beta-Lactam Aztreonam (Azt) In Pseudomonas Aeruginosa. By Incorporating Hydrophilic Substituents Onto The Aryl Nucleus,We Found A Morpholine Analogue That Possessed Improved Solubility,Retained Activity In Vitro,And Displayed Potentiation Activity In Vivo In A Rat Model Of P. Aeruginosa Pneumonia. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2006.08.037