CAS: 83-44-3; (R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-Dihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Pentanoic Acid

上下游产品

CAS号3245-38-3 脱氧胆酸甲酯 | CAS号28050-47-7 Methyl 3α-hydro... | CAS号27240-83-1 5β-胆酸-3α,12α-二醇... | CAS号434-13-9 石胆酸 | CAS号4472-02-0 5.beta.-Chol-9 ... | CAS号560-62-3 9-羟基雄烯二酮 | CAS号1093397-61-5 9alpha-hydroxy-... | CAS号1093397-63-7 5β-androst-9(11... | CAS号571-49-3 9(11), (5-BETA)... | CAS号360-65-6 甘氨脱氧胆酸 | CAS号3245-38-3 脱氧胆酸甲酯 | CAS号15173-30-5 5b-Cholan-24-oi... | CAS号434-13-9 石胆酸 | CAS号513-49-5 (S)-(+)-2-氨基丁烷 | CAS号2287-93-6 Cholan-24-oic a... | CAS号2387-23-7 N,N’-二环己基脲 | CAS号516-50-7 牛磺脱氧胆酸

胆酸置于sodium Tetrahydroborate,N-溴代丁二酰亚胺(Nbs),溶剂黄146体系中,用 四氢呋喃,二氯甲烷,水,丙酮 作为反应溶剂,化学反应 14.0H,反应生成 去氧胆酸
参考文献:胆酸新颖便捷合成脱氧胆酸
标题:胆酸新颖便捷合成脱氧胆酸
摘要:在本文中,提出了一种从胆酸 (2) 合成脱氧胆酸 (1) 的新颖且实用的方法.合成途径包括通过选择性氧化从化合物2中得到酸(20),然后20与对甲苯磺酰肼(23)缩合形成腙(21).随后,通过nabh 4 还原的三步反应过程反应生成产物1.总收率达到62.9%,HPLC纯度为100.00%.所有化合物的结构确认均使用 1 H NMR 和 13 C NMR 光谱以及hrms 进行.
DOI:10.1021/acs.Oprd.4C00121

专利信息

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-4354972-A
优先权日:1981-06-29
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. These syntheses include the steroid compounds and processes for their preparation. n An object of the invention is to provide syntheses which are applicable to materials which are readily available in good supply for converting such materials to steroids which are useful and desirable in the manufacture of pharmaceutical products. n More particularly, I have sought to discover processes and intermediate compounds useful in the synthesis of 24, 25-dihydroxycholesterol from hyodeoxycholic acid or lithocholic acid which are constituents of, and readily available from, animal bile.

专利号:US-7659391-B2
优先权日:2001-11-05
标 题:Method for the in vitro synthesis of short double stranded RNAs
发明人：DE BACKER MARIANNE DENISE; HARRIS ADAM N
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention relates to the field of synthesis of short double-stranded RNAs. An in vitro transcription method using bacteriophage polymerases and target sequence-specific single-stranded DNA oligonucleotides as templates is disclosed. The present invention finds particularly advantageous use in the synthesis of short interfering RNAs (siRNAs) that have been shown to function as key intermediates in triggering sequence-specific RNA degradation during posttranscriptional gene silencing in plants and RNA interference in invertebrates and vertebrate systems.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.