CAS: 22161-81-5; (S)-2-(3-Benzoylphenyl)Propanoic Acid

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CAS号60658-04-0 2-(3-苯甲酰基苯基)丙酸乙酯 | CAS号22071-15-4 酮洛芬 | CAS号59512-44-6 3-benzoyl-α-met... | CAS号57872-48-7 methyl α-(m-ben... | CAS号114315-58-1 ketoprofen 2-ch... | CAS号39172-32-2 2-(3-溴苯基)-2-甲基-... | CAS号17983-62-9 1-[3-(trimethyl... | CAS号2142-63-4 3-溴代苯乙酮 | CAS号66067-43-4 3-乙基二苯甲酮

3-(3-Benzoyl-Phenyl)-2S,3R-Dimethyl-Oxirane-2-Carboxy-5-Methyl-2-(1-Methyl-1-Phenyl-Ethyl)-Cyclohexane Ester置于sodium Carbonate,双氧水,溶剂黄146体系中,用 二氯甲烷,水 用作溶剂,化学反应 10.0H,以85.6%的收率获得右旋酮洛芬
参考文献:一种右旋酮洛芬中间体的合成方法
标题:一种右旋酮洛芬中间体的合成方法
摘要:本发明属于医药技术领域,具体涉及一种右旋酮洛芬中间体的合成方法,利用darzens反应的不对称合成制备右旋酮洛芬的中间体,该方法能够提高反应的选择性,降低原料的损耗,提高收率且简化操作流程,有利于实现工业化生产.

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-2012029226-A1
优先权日:2009-02-06
标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives
发明人：KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.

专利号:US-4097522-A
优先权日:1975-06-05
标 题:Synthesis of m-benzoyl-hydratropic acid
发明人：BAIOCCHI LEANDRO
权利人:ACRAF
摘要:A process is provided for the production of m-benzoyl-hydratropic acid which comprises heating the reaction mixture obtained from the condensation of 2-benzoyl-cyclohexanone and pyruvic acid, its esters or salts, at a temperature of 200° to 230° and in the presence of an acid catalyst.

专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).

专利号:US-2012232225-A1
优先权日:2009-08-26
标 题:Synthesis and isolation of dendrimer systems
发明人：BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL
权利人:BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).

专利号:US-9402911-B2
优先权日:2011-12-08
标题:Multifunctional small molecules
发明人：BAKER JR JAMES R; HUANG BAOHUA M; THOMAS THOMMEY P
权利人:UNIV MICHIGAN REGENTS
摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.