CAS: 320-49-0; 2-Bromo-5-Hydroxybenzotrifluoride

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CAS号98-17-9 3-三氟甲基苯酚 | CAS号393-36-2 4-溴-3-(三氟甲基)苯胺 | CAS号400-72-6 4-溴-3-(三氟甲基)苯甲醚 | CAS号156605-95-7 1-溴-4-乙氧基-2-(三氟甲基)苯

间三氟甲基苯酚置于溶剂黄146,Potassium Bromide体系中,用 水,溶剂黄146 用作溶剂,以69%的收率获得3-三氟甲基-4-溴苯酚
参考文献:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
标题:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
摘要:以 Kbr 和 Znal-Bro3--层状双氢氧化物(缩写为 Znal-Bro3--Ldhs)作为溴化试剂,成功开发了苯酚的区域选择性单溴化反应.对位点比较有利,如果对位点被占用,则邻位点优先.该反应具有优异的区域选择性,廉价的溴化试剂,反应条件温和,原子经济性高,底物范围广等特点,为溴代苯酚的合成提供了一种有效的方法.
Doi:10.3390/molecules25040914

专利信息

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof

专利号:CN-115960074-A
优先权日:2022-05-27
标题 :A class of fluorine-containing ferroelectric liquid crystal molecules containing a heteroatom six-membered alicyclic ring and its synthesis method

专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof