CAS: 503614-91-3; Ethyl 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxopiperidin-1-yl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxylate

上下游产品

CAS号675-20-7 2-氮己环酮 | CAS号473927-64-9 6-(4-碘苯基)-1-(4-... | CAS号545445-44-1 5,6-二氢-3-(4-吗啉基... | CAS号473927-63-8 (2Z)-氯[(4-甲氧基苯基... | CAS号881386-12-5 ethyl 6-(4-(5-b... | CAS号104-94-9 对甲氧基苯胺 | CAS号27143-07-3 [(4-甲氧基苯基)肼基]氯乙酸乙酯 | CAS号1415831-80-9 1-(4-iodophenyl... | CAS号1267610-26-3 1-(4-氨基苯基)-5,6-...

N-苯基-2-哌啶酮置于五氯化磷,硫酸,四丁基溴化铵,硝酸,一水合肼,三乙胺,Potassium Iodide,Sodium Hydroxide体系中,用 乙醇,二氯甲烷,水,N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应 3.5H,反应生成 4,5,6,7-四氢-1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代-1-哌啶基)苯基]-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯
参考文献:Process For The Preparation Of Apixaban And Intermediates Thereof
标题:Process For The Preparation Of Apixaban And Intermediates Thereof
摘要:该发明涉及一种新型的阿匹沙班制备工艺.此外,该发明还涉及一种从非常基本和廉价的原料苯胺(广泛商业可获得)制备阿匹沙班中间体的工艺.该发明提供了一种使用不同合成步骤顺序制备阿匹沙班的工艺,并且不涉及乌尔曼反应的使用.

专利信息

专利号:WO-2014072884-A1
优先权日:2012-11-12
标 题 :Process for the synthesis of apixaban
发明人：JAYARAMAN VENKAT RAMAN; PATEL NILAV; BORSANIYA MANOJ; KANZARIYA KAMLESH; RANA PIYUSH; SHAH SUDHIR; PANCHASARA DINESH; TOMER SANJIV
权利人:ALEMBIC PHARMACEUTICALS LTD; JAYARAMAN VENKAT RAMAN
摘要:The present invention relates to the Process for the preparation of Apixaban and novel intermediates useful in the synthesis of Apixaban (I).

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.

专利号:US-9920051-B2
优先权日:2014-10-15
标题:Key intermediates and impurities of the synthesis of apixaban: apixaban glycol esters
发明人：BRASOLA ELENA; TOMASI FILIPPO
权利人:F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.

专利号:US-2003181466-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:US-2005245566-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:EP-3009435-A1
优先权日:2014-10-15
标题:Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban