CAS: 5750-76-5; 2,4,5-Trichloropyrimidine

相似化合物

1780-40-1 6554-61-6 1780-27-4

上下游产品

CAS号1820-81-1 5-氯尿嘧啶 | CAS号1042434-76-3 2-((2,5-二氯嘧啶-4-... | CAS号293292-36-1 1-(2,5-二氯嘧啶-4-基... | CAS号274-56-6 吡唑并[1,5-a]吡啶 | CAS号1224709-13-0 3-(2,5-dichloro... | CAS号89180-51-8 2,5-二氯嘧啶-4-胺 | CAS号22536-67-0 2,5-二氯嘧啶 | CAS号761440-16-8 2,5-二氯-N-[2-(异丙... | CAS号5750-74-3 2,5-二氯-4-甲氧基嘧啶

5-氯尿嘧啶置于4-二甲氨基吡啶,氯化亚砜,三光气体系中,化学反应 10.0H,以91%的收率获得产物2,4,5-三氯嘧啶
参考文献:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
标题:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
摘要:用碳酸二(三氯甲基)酯(btc)和socl 2氯化羟基氮杂芳烃已经通过与5重量%的4-二甲基氨基吡啶(dmap)作为催化剂回流而有效地进行.各种底物都可以高产率氯化.所获得的氯化氮杂芳烃可通过简单的后处理直接直接用于大规模的一锅合成.
DOI:10.1021/acs.Oprd.9B00407

专利信息

专利号:US-2015336900-A1
优先权日:2012-10-29
标题 :Process for the Synthesis of Etravirine and Its Intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The invention discloses the synthesis of Etravirine via intermediate 4-((4-amino-5-bromo-6-chloropyrimidin-2-yl) amino)benzonitrile and process for the preparation of Etravirine of the formula-I.

专利号:WO-2025104624-A1
优先权日:2023-11-14
标题 :Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol
发明人：ALEXANDER KATY LOUISE; ANSARI ZARRIN FAZAL KHADIJA; DANIELS DAVID SYDNEY BERNARD; HASSEL LUKE HARRY; KEEN STEPHEN PHILIP; SCOTT JEREMY PETER; SCOTT REUBEN JOHN; SIMMONS JOHATHAN ANDREW; STOLL EMMA LOUISE; TRINDADE ALEXANDRE FONSECA; VICINI ANNA CHIARA
权利人:PFIZER
摘要:This disclosure relates novel methods to prepare 1,5-anhydro-3-({5-chloro-4-[4- fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2- yl}amino)-2,3-dideoxy-D-threo-pentitol, and hydrates and stereoisomers thereof, as well as intermediates, including solid forms of the intermediates, useful for the preparation of such compounds and the synthesis of said intermediates.

专利号:WO-2014080341-A1
优先权日:2012-11-21
标题 :New process for the synthesis of trichloropyrimidine-amine derivatives
发明人：Czibula László; Dobay László; SZAVICSKÓ KRISZTINA; KISS-BARTOS DOROTTYA; Nagyné Bagdy Judit
权利人:RICHTER GEDEON NYRT
摘要:The invention relates to a new process for the synthesis of 2-(N-methyl)-amino-4,5,6- trichloro-l,3-pyrimidine, which is more economical than the known process, as well as the new compounds synthesized as intermediates in the process: 2-(N',N'-dimethylamino- methylene)-amino-4,5,6-trichloro-l,3-pyrimidine and 2-(N-formyl)-amino-4,5,6-trichloro-l,3- pyrimidine.

专利号:US-7122670-B2
优先权日:2003-09-05
标题:Selective synthesis of CF3-substituted pyrimidines
发明人：KATH JOHN CHARLES; RICHTER DANIEL TYLER; LUZZIO MICHAEL JOSEPH
权利人:PFIZER
摘要:The present invention relates to a method of making a compound of the formula n nwherein X 1 , X 2 and R 3 —R 4 are as defined herein. The method includes reacting a compound of the formulan n nwith an amine of formula 3 (HNR 3 R 4 ) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.

专利号:US-11186836-B2
优先权日:2016-06-16
标 题 :Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
发明人：WATTS RICHARD EDWARD
权利人:HAYSTACK SCIENCES CORP
摘要:The present disclosure relates to multifunctional molecules, including molecules according to formula (I):n n([(B 1 ) M -D-L 1 ] Y -H 1 ) O -G-(H 2 -[L 2 -E-(B 2 ) K ] W ) P ,   (I)n nwherein G, H 1 , H 2 , D, E, B 1 , B 2 , M, K, L 1 , L 2 , O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.

专利号:US-2019169607-A1
优先权日:2016-06-16
标题:Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules