CAS: 64325-78-6; N-(9-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-2-yl)-9H-Purin-6-yl)Benzamide

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110764-72-2 81246-82-4 136834-21-4

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CAS号40615-36-9 4,4'-二甲氧基三苯基氯甲烷 | CAS号4546-72-9 N-苯甲酰基-2'-脱氧腺苷 | CAS号118352-75-3 Triethylammoniu... | CAS号958-09-8 2'-脱氧腺苷 | CAS号17331-22-5 5-O-(4,4-二甲氧基三苯... | CAS号98796-53-3 DMT-dA(bz)亚磷酰胺单体 | CAS号64723-02-0 N-benzoyl-3',5'... | CAS号4546-72-9 N-苯甲酰基-2'-脱氧腺苷 | CAS号958-09-8 2'-脱氧腺苷 | CAS号98796-53-3 DMT-dA(bz)亚磷酰胺单体 | CAS号17331-22-5 5-O-(4,4-二甲氧基三苯...

Triethylammonium 6-N-Benzoyl-2'-Deoxy-5'-O-(4,4'-Dimethoxytrityl)Adenosine 3'-H-Phosphonate置于三甲基乙酰氯,乙二醇体系中,化学反应 0.33H,以87%的收率获得产物n6-苯甲酰基-5'-O-(4,4'-二甲氧基三苯基)-2'-脱氧腺苷
参考文献:保护的脱氧核苷和寡脱氧核苷酸h-膦酸酯的脱膦酰化作用
标题:保护的脱氧核苷和寡脱氧核苷酸h-膦酸酯的脱膦酰化作用
摘要:四个5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧核糖核苷3'-H-膦酸酯1(b = 4,5,6和7)转化为其部分保护的核苷前体3(b = 4,5,6和7在非常好分离收率分别)进行说明.所用的方法也适用于保护的寡核苷酸h-膦酸酯嵌段的去膦酰基化.
DOI:10.1016/s0040-4039(99)01185-5

专利信息

专利号:US-5703223-A
优先权日:1994-09-02
标题 :Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
发明人：WICKSTROM ERIC; LE BEC CHRISTINE
权利人:UNIV JEFFERSON
摘要:The present invention provides a method for producing an oligonucleotide having stereospecific substituted phosphonate linkages by use of a pentavalent Grignard coupling reaction on a solid phase support. The method can be used for automated synthesis of oligonucleotides having sequential equatorial or axial stereospecific substituted phosphonate linkages.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-4849513-A
优先权日:1983-12-20
标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-12337291-B2
优先权日:2017-09-11
标 题 :Guide RNA synthesis system and method
发明人：DABROWSKI PAUL; GERLINGHAUS FABIAN; KELSO REED; WALKER II JOHN ANDREW
权利人:SYNTHEGO CORP
摘要:The present invention provides improved automated systems and methods for synthesis of biopolymers including DNA and RNA. The automated systems and methods represent a number of improvements over existing systems for multiplex synthesis of biopolymers in a combinatorial fashion.

专利号:US-7019127-B2
优先权日:1997-08-13
标 题 :Solution phase synthesis of oligonucleotides
发明人：REESE COLIN BERNARD; SONG QUANLAI
权利人:AVECIA LTD
摘要:A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate diester is oxidised in situ with a sulfur transfer agent to produce the phosphorothioate triester. Preferably, the H-phosphonate and alcohol are protected nucleosides or oligonucleotides. Oligonucleotide H-phosphonates which can be used in the formation of phosphorothioate triesters are also provided.

专利号:US-5118800-A
优先权日:1983-12-20
标 题 :Oligonucleotides possessing a primary amino group in the terminal nucleotide
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.