CAS: 77-90-7; Tributyl 2-Acetoxypropane-1,2,3-Tricarboxylate

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CAS号108-05-4 乙酸乙烯酯 | CAS号77-94-1 柠檬酸三丁酯 | CAS号108-24-7 乙酸酐 | CAS号64-19-7 冰醋酸

乙酸乙烯酯,柠檬酸三丁酯置于potassium Tert-Butylate,1-Ethyl-3-Methylimidazolium Tetrafluoroborate体系中,用 四氢呋喃 作为反应溶剂,化学反应 12.0H,以81%的收率获得产物乙酰柠檬酸三丁酯
参考文献:N-Heterocyclic Carbene-Catalyzed Synthesis Of Acetyltributylcitrate Via A Transesterification Reaction
标题:N-Heterocyclic Carbene-Catalyzed Synthesis Of Acetyltributylcitrate Via A Transesterification Reaction
摘要:A New Methodology For The Synthesis Of A Green Plasticizer Acetyltributylcitrate Through A Transesterification Reaction Was Developed. Under The Catalysis Of Alkyl-Substituted Imidazol-Type N-Heterocyclic Carbenes,Tributyl Citrate Can React With Vinyl Acetate Smoothly To Give Atbc In High Yield. (C) 2013 Lin He And Bin Dai. Published By Elsevier B.V. On Behalf Of Chinese Chemical Society. All Rights Reserved.
DOI:10.1016/j.Cclet.2013.11.034

专利信息

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

专利号:WO-2013170430-A1
优先权日:2012-05-14
标 题:Process for synthesizing acetyl citrate
发明人：GUO KAI; FANG ZHENG; OUYANG PINGKAI; ZHOU YANGZHI; WEI PING; JIANG MIN; XU HONG
权利人:NANJING UNIVERSITY OF TECHNOLOGY; GUO KAI; FANG ZHENG; OUYANG PINGKAI; ZHOU YANGZHI; WEI PING; JIANG MIN; XU HONG
摘要:A process for synthesizing acetyl citrate catalytically, comprising the following steps: 1) preparation of a catalyst: dipping woody active carbon into an acid solution, mixing, loading and fixing at room temperature, filtrating and drying to obtain the catalyst loaded and fixed with active carbon, 2) synthesis of citrate: into a reactor, adding (hydration) citric acid and alcohol, and a composite catalyst composed of the catalyst loaded and fixed with active carbon from step 1) and one of acids selected from H2SO4, benzene sulfonic acid, p-toluenesulfonic acid, methanesulfonic acid, NaHSO4 or trifluoromethanesulfonic acid, carrying out esterification at 130℃-160℃ filtrating and dealcoholizing the reaction mixture to obtain the crude critrate; 3) synthesis of acetyl citrate: adding acid anhydride into crude citrate from step 2), acylating at 60℃-90℃, and post treating the reaction product to obtain the end product of acetyl citrate. The composite catalyst is used in the esterification and acylation reaction of the present invention, which results in less amount of catalyst, high efficiency, good product quality, compact and integrated process, and therefore, the process is suitable for industrialized application.

专利号:US-8884051-B2
优先权日:2010-10-20
标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
发明人：MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C
权利人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C; BIOFORMIX INC
摘要:The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

专利号:EP-2354120-A1
优先权日:2003-08-20
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE
权利人:XENOPORT INC
摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

专利号:US-2010278715-A1
优先权日:2009-04-29
标 题:Systems, Devices, and/or Methods Regarding Specific Precursors or Tube Control Agent for the Synthesis of Carbon Nanofiber and Nanotube
发明人：KHE NGUYEN
权利人:TH LLC
摘要:Certain exemplary embodiments can comprise, via a tube control agent (TCA) and a metallic catalyst, producing a carbon nanotube. At least some carbon used to form the carbon nanotube can be obtained from a plant, a cellulose product, and/or a cellulosic product. At least some of the carbon can be converted into powder.

专利号:US-2023339839-A1
优先权日:2022-04-24
标题:Synthesis method of alpha-hydroxycarboxylic acid ester
发明人：MENG ZHONGLEI; QIN RONGXIU; GAO SHOUNA; HU GUOJIAO; WEN RUSI; Liao Zhongqiu; LIANG ZHONGYUN; HU LIHONG; ZHOU YONGHONG
权利人:GUANGXI FORESTRY RES INSTITUTE
摘要:A synthesis method of alpha-hydroxycarboxylic acid ester is provided. In the method, an alpha-hydroxycarboxylic acid and an alcohol are taken as raw materials, one or more of boric acid, metaboric acid, pyroboric acid, and boric anhydride is taken as a catalyst, and one of cyclohexane, toluene, benzene, and alcohols is taken as a water-carrying agent. A reaction temperature is kept in range of 100-160° C., produced water is separated by an oil-water separator, and the alpha-hydroxycarboxylic acid ester is synthesized directly. After an esterification reaction, the water-carrying agent and unreacted alcohol are distilled by vacuum fractionation to obtain a crude product, and refined alpha-hydroxycarboxylic acid ester is obtained by performing neutralization, water washing, and vacuum rectification on the crude product. The alpha-hydroxycarboxylic acid ester prepared by the method has high purity and light color, and can be used as green solvent, surfactant, chiral resolution agent and plasticizer.