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CAS号74-96-4 溴乙烷 | CAS号352-97-6 乙酸胍 | CAS号463-00-3 4-胍基丁酸 | CAS号811-51-8 乙硫醇钠 | CAS号594-44-5 乙基磺酰氯 | CAS号627-04-3 (乙基硫代)乙酸 | CAS号102-06-7 二苯胍 | CAS号3088-46-8 Propanenitrile,... | CAS号55-67-4 benzyl-guanidin... | CAS号112-65-2 十二胍 | CAS号16136-32-6 1-[2-(Diphenylm...

硫脲,溴乙烷 以 乙醇 用作溶剂,化学反应 1.0H,反应生成S-乙基异硫脲氢溴酸盐
参考文献:通过n-氯代琥珀酰亚胺氯磺化反应从s-烷基异硫脲盐中方便,环保地合成磺酰氯
标题:通过n-氯代琥珀酰亚胺氯磺化反应从s-烷基异硫脲盐中方便,环保地合成磺酰氯
摘要:摘要 已经开发了一种方便,实用和环境友好的合成磺酰氯的方法.由s-烷基异硫脲盐以中等至优异的收率合成结构多样的磺酰氯,其可以容易地由易于获得的烷基卤化物或甲磺酸酯和廉价的硫脲通过n-氯代琥珀酰亚胺氯磺化制备.在大规模合成中,可以将来自"废水"的副产物琥珀酰亚胺与次氯酸钠(漂白剂)方便地转化为起始试剂n-氯琥珀酰亚胺,以使该方法具有可持续性. 已经开发了一种方便,实用和环境友好的合成磺酰氯的方法.由s-烷基异硫脲盐以中等至优异的收率合成结构多样的磺酰氯,其可以容易地由易于获得的烷基卤化物或甲磺酸酯和廉价的硫脲通过n-氯代琥珀酰亚胺氯磺化制备.在大规模合成中,可以将来自"废水"的副产物琥珀酰亚胺与次氯酸钠(漂白剂)方便地转化为起始试剂n-氯琥珀酰亚胺,以使该方法具有可持续性.
Doi:10.1055/s-0033-1338743

专利信息

专利号:US-2006264608-A1
优先权日:2001-08-03
标题 :Bi-directional synthesis of oligoguanidine transport agents
发明人：WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
权利人:WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
摘要:Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.

专利号:US-8471010-B2
优先权日:2008-05-13
标题:Synthesis of dihydrothieno[3,2-d]pyrimidine diols
发明人：FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H
权利人:FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.

专利号:US-2011105786-A1
优先权日:2009-11-02
标 题 :Creatinol o-phosphate and synthesis method thereof
发明人：ZHANG GUOJI; ZHANG JIASHU
权利人:TIANJIN TIANCHENG PHARMACEUTICAL CO LTD
摘要:A creatinol O-phosphate is formed by chemically reacting a creatinol sulfate of creatinol compound with sulfuric acid to form a protected creatinol sulfate as a transition state of the synthesis process of the creatinol O-phosphate, wherein the protected creatinol is further reacted with one of P 2 O 5 , CIPO 3 H 2 , and POCl 3 to form the creatinol O-phosphate. The method of producing the protected creatinol sulfate includes a step of adding sulfuric acid into a creatinol sulfate to form a protected creatinol sulfate as the protected functional group. Therefore, the creatinol O-phosphate is formed by the process including the steps of chemically reacting the protected creatinol sulfate with one of POCl 3 , CIPO 3 OH 2 , and P 2 O 5 to form a creatinol O-phosphate solution; and crystallizing the creatinol O-phosphate solution to obtain crystallized creatinol O-phosphate.

专利号:US-2014256987-A1
优先权日:2013-03-09
标 题 :Creatinol O-phosphate and synthesis method thereof
发明人：ZHANG GUOJI
权利人:ZHANG GUOJI; TIANJIN TIANCHENG PHARMACEUTICAL CO LTD
摘要:A creatinol O-phosphate is formed by chemically reacting a creatinol sulfate of creatinol compound with sulfuric acid to form a protected creatinol sulfate as a transition state of the synthesis process of the creatinol O-phosphate, wherein the protected creatinol is further reacted with one of P 2 O 5 , CIPO 3 H 2 , and POCl 3 to form the creatinol O-phosphate. The method of producing the protected creatinol sulfate includes a step of adding sulfuric acid into a creatinol sulfate to form a protected creatinol sulfate as the protected functional group. Therefore, the creatinol O-phosphate is formed by the process including the steps of chemically reacting the protected creatinol sulfate with one of POCl 3 , ClPO 3 OH 2 , and P 2 O 5 to form a creatinol O-phosphate solution; and crystallizing the creatinol O-phosphate solution to obtain crystallized creatinol O-phosphate.

专利号:US-2011105797-A1
优先权日:2009-11-02
标题:Creatinol sulfate and synthesis method thereof
发明人：ZHANG GUOJI; ZHANG JIASHU
权利人:TIANJIN TIANCHENG PHARMACEUTICAL CO LTD
摘要:A chemical compound of creatinol sulfate is formed by chemically reacting N-methyl-amino-ethanol, cyanamide, with sulfuric acid to produce the creatinol sulfate with relatively higher yield rate and purity, wherein the mol ratio of N-methyl-amino-ethanol, sulfuric acid, and cyanamide is approximately 2:1:2.

专利号:ES-2392920-T3
优先权日:2008-05-13
标 题:Synthesis of dihydrothiene [3,2-d] pyrimidine diols and similar pyrimidine diols