CAS: 114152-23-7; 2-(2,3,6-Trifluorophenyl)Acetic Acid

相似化合物

114152-21-5 132992-28-0 653-21-4

上下游产品

Ethyl 2,3,6-Trifluorophenylacetate 114152-22-6
2,3,6-三氟苯乙腈 2-(2,3,6-Trifluorophenyl)Acetonitrile 114152-21-5

2,3,6-三氟苯甲醇置于盐酸,Sodium Hydroxide,氯化亚砜,硫酸,三乙胺体系中,用 乙醇,二氯甲烷,水 用作溶剂,化学反应生成2,3,6-三氟苯基乙酸
参考文献:1-Cyclopropyl-6-Fluoro-8-Alkyl-1,4-Dihydro-4-Oxo-Quinoline-3-Carboxylic
标题:1-Cyclopropyl-6-Fluoro-8-Alkyl-1,4-Dihydro-4-Oxo-Quinoline-3-Carboxylic
摘要:4-氧喹啉-3-羧酸化合物的结构式:其中r.Sup.2为1-吡咯烷基,可以有1到2个取代基,所选自以下组合:(I) C.Sub.1-C.Sub.6烷基,(II) 氨基-(C.Sub.1-C.Sub.6)烷基,该氨基可以选为1或2个取代基,所选自c.Sub.1-C.Sub.6烷基,C.Sub.1-C.Sub.6烷酰基和c.Sub.1-C.Sub.6氧代羰基,(III) 氨基,可以被1或2个取代基所取代,所选自c.Sub.1-C.Sub.6烷基,苯基(C.Sub.1-C.Sub.6)烷基,C.Sub.1-C.Sub.6氧代羰基和c.Sub.1-C.Sub.6烷酰基,以及(Iv) 2-氧代-1,3-二氧杂环戊烯基氨基,该氨基被c.Sub.1-C.Sub.6烷基取代;或1-哌啶基,可以有1到3个取代基,所选自氧代,羟基,卤素和c.Sub.1-C.Sub.6烷基,R.Sup.3为c.Sub.1-C.Sub.6烷基,或其药学上可接受的盐,这些化合物具有出色的抗微生物活性,因此可用作抗微生物药物,并且含有该化合物作为活性成分的药物组合物.

专利信息

专利号:US-11897857-B2
优先权日:2019-02-15
标 题 :Isotopically-stabilized tetronimide compounds
发明人：OLSEN MARK JON; SEERDEN JEAN PAUL
权利人:UNIV MIDWESTERN
摘要:Isotopically-stabilized tetronimide compounds comprising one or more deuterium atoms, derivatives, and intermediates, thereof, including methods for their synthesis, pharmaceutical compositions thereof, and methods of using these compounds to interact with target molecules in cell-free samples, cell- and tissue-based assays, animal models, and in a subject are disclosed. One aspect relates to molecules that modulate the expression or catalytic activity of aspartyl (asparaginyl) β-hydroxylase (ASPH) within or on the surface of a cell. Other aspects of the invention relate to use of the molecules disclosed herein to diagnose, ameliorate, or treat cell proliferation disorders and related diseases. Related aspects include uses of the compounds to modulate the activity of viruses, as anti-hyperlipidemia agents, and as agents to ameliorate or treat thrombosis and related cardiovascular and metabolic disorders.

专利号:US-9487523-B2
优先权日:2012-03-14
标题 :Process for making CGRP receptor antagonists
发明人：BELYK KEVIN M; CLEATOR EDWARD; KUO SHEN-CHUN; MALIGRES PETER EMMANUEL; XIANG BANGPING; YASUDA NOBUYOSHI; YIN JIANGUO
权利人:MERCK SHARP & DOHME
摘要:The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine, utilizing a highly effective spiroacid synthesis.