CAS: 138890-62-7; 2H-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide, 4-(Ethylamino)-3,4-Dihydro-2-(3-Methoxypropyl)-, 1,1-Dioxide, (4R)-

上下游产品

CAS号154127-42-1 (S)-3,4-二氢-4-羟基... | CAS号75-04-7 乙胺 | CAS号1448780-04-8 brinzolamide maleate | CAS号150937-43-2 布林佐胺-d5 | CAS号160982-13-8 (S)-6-氯-2-(3-甲氧... | CAS号36157-40-1 2,5-二氯-3-乙酰基噻吩 | CAS号160982-09-2 1-(2-(苄基硫代)-5-氯...

在 Sodium Thiomethoxide体系中,用 甲醇 用作溶剂,化学反应 12.0H,以83%的收率获得布林佐胺
参考文献:一种手性胺基化合物及其中间体的制备方法
标题:一种手性胺基化合物及其中间体的制备方法
摘要:本发明公开了一种布林佐胺及其中间体的制备方法.本发明的制备方法包括下述步骤:在溶剂中,将式d化合物与硫醇盐进行如下所示的脱保护反应,即可;其中,式d化合物中,X选自o或nme;X为o时,Y为me,X为nme时,Y为h;N选自0,1,2,3,4或5;每个r独立地为no2或cn;所述的硫醇盐为硫醇与金属形成的盐,表示为rs‑m+;其中,M+为碱金属离子,具体可选自li+,Na+,K+,Ru+和cs+中的一种或多种;R为c14‑24烷基.本发明的制备方法操作简便,反应条件温和,收率高,产品质量好,适于工业化生产.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:WO-2022055467-A1
优先权日:2020-09-08
标题:Certain new 4-(2-((5-(substitutedamino)-1,3,4-thiadiazole-2-yl)thio)acetyl)benzenesulphoneamide derivatives and a method for the synthesis of said derivatives
发明人：KAPLANCIKLI ZAFER ASIM; ÖZKAY YUSUF; BEYDEMÄ°R ŞÜKRÃœ; ILGIN SINEM; ATLI EKLÄ°OÄžLU ÖZLEM; OSMANÄ°YE DERYA; LEVENT SERKAN; ACAR ÇEVÄ°K ULVIYE; SAÄžLIK BEGÃœM NURPELIN; KAYA ÇAVUÅžOÄžLU BETÃœL; KORKUT ÇELÄ°KATEÅž BÜŞRA; NEZÄ°R DENIZ; BÃœYÃœKEMÄ°R OYA; DEMÄ°R YELIZ; KARADUMAN ABDULLAH BURAK
权利人:ANADOLU UENIVERSITESI
摘要:The invention relates to a certain new 4-(2-((5-(substitutedamino)-1,3,4-thiadiazole-2-yl)thio)acetyl)benzenesulphonamide derivatives for use in pharmaceutics, chemical and pharmaceutical industry, and to a method for the synthesis of said derivatives.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:EP-2054420-B1
优先权日:2006-08-02
标题:Benzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamides as inhibitors of carbonic anhydrase and the intermediates for production thereof
发明人：MATULIS DAUMANTAS; DUDUTIENE VIRGINIJA; MATULIENE JURGITA; MISTINAITE LINA
权利人:BIOTECHNOLOGIJOS INST
摘要:The invention is related to novel compounds - benzimidazo[1,2-c][1,2,3]thiadiazole sulfonamides, corresponding to the general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progression such as glaucome. The compounds of formula (I) inhibits enzymes such as carbonic anhydrases and metallo proteinases. This invention is also related to new intermediate compounds which are used for the synthesis of sulfonamides of formula (I).

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-5470973-A
优先权日:1994-10-03
标 题 :Synthesis of sulfonamide intermediates
发明人：HOFF ROMAN
权利人:ALCON LAB INC
摘要:Enantioselective syntheses of (S)-6-chloro-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazin-4-ol 1,1-dioxide and related compounds are described.