CAS: 1707-77-3; (1S,2S)-1,2-Bis((R)-2,2-Dimethyl-1,3-Dioxolan-4-yl)Ethane-1,2-Diol

上下游产品

CAS号69-65-8 甘露醇 | CAS号67-64-1 丙酮 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号116-11-0 2-甲氧基丙烯 | CAS号51051-82-2 [1,2-bis(2,2-di... | CAS号4306-35-8 1-(2,2-dimethyl... | CAS号3427-24-5 trans-3,4-dideh... | CAS号50-70-4 山梨醇 | CAS号106571-12-4 1 2:5 6-DI-O-IS... | CAS号17299-07-9 (2R,5R)-2,5-己二醇 | CAS号51268-87-2 (S)-3-(2,2-二甲基-... | CAS号198402-59-4 (S)-4,5-异亚丙基-2-戊烯溴 | CAS号20720-17-6 D-Mannitol,1,2:... | CAS号24808-13-7 D-Altritol,3,4-... | CAS号22323-82-6 (S)-(+)-甘油醇缩丙酮 | CAS号22323-80-4 L-甘油醛缩丙酮 | CAS号83400-91-3 2,2-二甲基-1,3-二氧戊... | CAS号1193-11-9 2,2,4-三甲基-1,3-二氧环戊烷

甘露醇置于zinc(II) Chloride体系中,用 丙酮 用作溶剂,化学反应 22.0H,以53%的收率获得双丙酮-D-甘露糖醇
参考文献:合成 2-Keto-3-Deoxy-D-Xylonate 和 2-Keto-3-Deoxy-L-Arabinonate 作为立体化学探针,用于证明硫化叶菌对 D-木糖和 L-阿拉伯糖的代谢混杂
标题:合成 2-Keto-3-Deoxy-D-Xylonate 和 2-Keto-3-Deoxy-L-Arabinonate 作为立体化学探针,用于证明硫化叶菌对 D-木糖和 L-阿拉伯糖的代谢混杂
摘要:2-酮基-3-脱氧的实用合成d-Xylonate(d-Kdx)和2-酮基-3-脱氧大号-Arabinonate(大号-Kda)依赖于2-的阴离子的反应-[(叔已开发出-丁基二甲基甲硅烷基)氧基]-2-(二甲氧基磷酰基)乙酸酯与对映纯甘油醛丙酮化物,然后对所得o-甲硅烷基-烯醇酯进行全局脱保护.这使我们能够确认来自古生菌sulfolobus Solfataricus的 2-酮-3-脱氧-D-葡萄糖酸醛缩酶表现出非常好的催化活性,可以催化这两种对映异构体的逆羟醛裂解得到丙酮酸和乙醇醛.这种醛缩酶对这些对映异构醛醇底物的立体化学混杂性证实了该生物体采用代谢混杂的途径来分解代谢 C5-糖d-木糖和l-阿拉伯糖.
Doi:10.1002/chem.201203489

专利信息

专利号:US-5219845-A
优先权日:1991-04-25
标题:Phosphonates as anti-inflammation agents
发明人：SALARI HASSAN; BITTMAN ROBERT
权利人:UNIV BRITISH COLUMBIA
摘要:The invention pertains to the synthesis and use as therapeutic agents of a group of substances with a glycerol backbone or aliphatic chain structure linked to a phosphorus atom and a polar head group. Depending on the polar head group, the substance has anti-cancer, anti-inflammatory, anti-allergy or anti-cardiovascular disease properties. Compounds of the formula: wherein n is 0 to 14 and R1 is an alkyl group of C12-C20, R2 is a methyl group, and wherein R3 is an inositol analog head group, a (CH2)mN+(CH3)3 group with m=2 to 10, a serine head group, or an ethanolamine head group, or of the formula wherein R1 and R2 are as described above, n=0 or 1, and R3 is (CH2)mN+(CH3)3 (m=2-10) are claimed. This invention also pertains to the synthesis and use as therapeutic agents of a group of substances that have no glycerol backbone but have an aliphatic chain structure linked directly to a phosphorus atom of the general formula R-P(O)(O-)OR' wherein R is a long-chain alkyl group such as hexadecyl or octadecyl and R' is a head group such as choline, glycerol, inositol, ethanolamine, or serine.

专利号:US-5369097-A
优先权日:1991-04-25
标题 :Phosphonates as anti-cancer agents
发明人：SALARI HASSAN; BITTMAN ROBERT
权利人:UNIV BRITISH COLUMBIA
摘要:This invention pertains to the synthesis and use as therapeutic agents of a group of substances with a glycerol backbone or aliphatic chain structure linked to a phosphorus atom and a polar head group. Depending on the polar head group, the substance has anti-cancer, anti-inflammatory, anti-allergy or anti-cardiovascular disease properties. Compounds of the formula: wherein n is 0 to 14 and R1 is an alkyl group of C12-C20, R2 is a methyl group, and wherein R3 is an inositol analog head group, a (CH2)mN+(CH3)3 group with m=2 to 10, a serine head group, or an ethanolamine head group, or of the formula wherein R1 and R2 are as described above, n=0 or 1, and R3 is (CH2)mN+(CH3)3(m=2-10 ) are claimed. This invention also pertains to the synthesis and use as therapeutic agents of a group of substances that have no glycerol backbone but have an aliphatic chain structure linked directly to a phosphorus atom of the general formula R-P(O)(O-)OR' wherein R is a long-chain alkyl group such as hexadecyl or octadecyl and R' is a head group such as choline, glycerol, inositol, ethanolamine, or serine.