CAS: 25781-92-4; 5-Chloro-2-Nitro-N-Phenylaniline

上下游产品

CAS号700-37-8 4-氯-2-氟硝基苯 | CAS号610-40-2 3,4-二硝基氯苯 | CAS号611-06-3 2,4-二氯硝基苯 | CAS号127-09-3 乙酸钠 | CAS号22316-45-6 乙酰基-5-氯-2-硝基二苯胺-N-乙酯 | CAS号22316-47-8 氧异安定 | CAS号22316-55-8 8-氯-1-苯基-1H-1,5... | CAS号68406-47-3 4-chloro-2-N-ph... | CAS号54986-47-9 6-Chloro-1,3-di... | CAS号61154-60-7 ethyl 2-[(5-chl... | CAS号61154-64-1 2-[(5-chloro-2-...

3,4-二硝基氯苯置于苯胺体系中,用 乙醇 用作溶剂,化学反应生成5-氯-2-硝基联苯胺
参考文献:Non-Peptidyl Tachykinin Receptor Antagonists
标题:Non-Peptidyl Tachykinin Receptor Antagonists
摘要:这项发明提供了一种新颖的公式ii的取代苯并咪唑,它们可用作快速激肽受体拮抗剂.这项发明还提供了治疗与快速激肽过剩有关的疾病的方法,包括向需要的哺乳动物中给予一系列取代苯并咪唑中的一种.这项发明还提供了包含本发明中一种或多种取代苯并咪唑与药用载体,稀释剂或赋形剂相关联的药物配方.A和ra-Re如描述中所定义.

专利信息

专利号:US-10150745-B2
优先权日:2015-03-24
标 题:Process for the preparation of clobazam and its intermediate
发明人：JAGTAP ASHUTOSH; GHARPURE MILIND; SHINDE NAVNATH; PATIL NAVNATH; SHAH CHIRAG; RAUT CHANGDEV; KRISHNMURTHY DHILEEPKUMAR
权利人:PIRAMAL ENTPR LTD
摘要:The present invention provides an improved process for the preparation of 8-chloro-1-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione (hereafter referred to as the compound (IV)), which is useful as a key intermediate for the synthesis of Clobazam (referred to as the compound (I)) 7-chloro-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione. The process of the present invention further involves transformation of the compound (IV) into Clobazam (I), comprising (a) reacting the compound (II) (as described herein) with monoalkyl malonate in the presence of a coupling agent to obtain the compound (III) (as described herein); followed by the cyclization using a base; (b) reacting the compound-IV (as described herein) obtained from step (a) with methylating agent. The process of the present invention involves formation of novel intermediates methyl 3-((4-chloro-2-(phenylamino)phenyl)amino)-3-oxopropanoate (IIIa) and 3-((4-chloro-2-(phenylamino)phenyl)amino)-3-oxopropanoic acid (V).

专利号:RU-2124009-C1
优先权日:1992-01-21
标题 :Derivatives of 1,5-benzodiazepine, method of their synthesis, pharmaceutical composition