CAS: 262368-30-9; N-(4-Aminophenyl)-N-Methyl-2-(4-Methylpiperazin-1-yl)Acetamide

上下游产品

N,4-二甲基-N-(4-硝基苯基)-1-哌嗪乙酰胺 N-Methyl-2-(4-Methylpiperazin-1-yl)-N-(4-Nitrophenyl)Acetamide 1139453-98-7

2-氯-N-甲基-N-(4-硝基苯基)乙酰胺置于palladium On Activated Charcoal,氢气体系中,用 甲苯 用作溶剂,化学反应生成N-(4-氨基苯基)-N,4-二甲基-1-哌嗪乙酰胺
参考文献:用于改善药代动力学特性的氘代尼达尼布的设计,合成和生物学评价
标题:用于改善药代动力学特性的氘代尼达尼布的设计,合成和生物学评价
摘要:尼达尼布是一种新型三联血管激酶抑制剂,可同时抑制三种生长因子.在体外和体内制备和评估了某些代谢活性位点的尼达尼布氘代衍生物.特别是,与尼达尼布相比,氘代化合物 Sklb-C2202 具有显着改善的药代动力学特性.这些努力为进一步研究 Sklb-C2202 的成药性奠定了基础.
Doi:10.1002/jlcr.3299

专利信息

专利号:US-11261158-B2
优先权日:2017-11-17
标 题:Synthesis of 2-indolinone derivatives
发明人：PIISOLA ANTTI; TOIS JAN
权利人:FERMION OY
摘要:The present disclosure relates to a preparation method of methyl (E)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate from methyl 2-oxoindoline-6-carboxylate using high reaction temperatures and a reaction solvent enabling azeotropic removal of acetic acid during the reaction.

专利号:JP-2023171763-A
优先权日:2017-11-17
标 题:Synthesis of 2-indolinone derivatives known as intermediates for producing nintedanib

专利号:CN-111465594-B
优先权日:2017-11-17
标题:Synthesis of 2-indolinones known as intermediates for the preparation of Nidamibu

专利号:EP-3710427-B1
优先权日:2017-11-17
标题:Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib

专利号:CA-3082714-A1
优先权日:2017-11-17
标 题 :Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib

专利号:JP-7382317-B2
优先权日:2017-11-17
标题:Synthesis of 2-indolinone derivatives known as intermediates for producing nintedanib